%0 Journal Article
%A Cortés-Ciriano, Isidro
%A Lee, Jake June-Koo
%A Xi, Ruibin
%A Jain, Dhawal
%A Jung, Youngsook L
%A Yang, Lixing
%A Gordenin, Dmitry
%A Klimczak, Leszek J
%A Zhang, Cheng-Zhong
%A Pellman, David S
%A Park, Peter J
%A Akdemir, Kadir C
%A Alvarez, Eva G
%A Baez-Ortega, Adrian
%A Beroukhim, Rameen
%A Boutros, Paul C
%A Bowtell, David D L
%A Brors, Benedikt
%A Burns, Kathleen H
%A Campbell, Peter J
%A Chan, Kin
%A Chen, Ken
%A Cortés-Ciriano, Isidro
%A Dueso-Barroso, Ana
%A Dunford, Andrew J
%A Edwards, Paul A
%A Estivill, Xavier
%A Etemadmoghadam, Dariush
%A Feuerbach, Lars
%A Fink, J Lynn
%A Frenkel-Morgenstern, Milana
%A Garsed, Dale W
%A Gerstein, Mark
%A Gordenin, Dmitry A
%A Haan, David
%A Haber, James E
%A Hess, Julian M
%A Hutter, Barbara
%A Imielinski, Marcin
%A Jones, David T W
%A Ju, Young Seok
%A Kazanov, Marat D
%A Klimczak, Leszek J
%A Koh, Youngil
%A Korbel, Jan O
%A Kumar, Kiran
%A Lee, Eunjung Alice
%A Lee, Jake June-Koo
%A Li, Yilong
%A Lynch, Andy G
%A Macintyre, Geoff
%A Markowetz, Florian
%A Martincorena, Iñigo
%A Martinez-Fundichely, Alexander
%A Miyano, Satoru
%A Nakagawa, Hidewaki
%A Navarro, Fabio C P
%A Ossowski, Stephan
%A Park, Peter J
%A Pearson, John V
%A Puiggròs, Montserrat
%A Rippe, Karsten
%A Roberts, Nicola D
%A Roberts, Steven A
%A Rodriguez-Martin, Bernardo
%A Schumacher, Steven E
%A Scully, Ralph
%A Shackleton, Mark
%A Sidiropoulos, Nikos
%A Sieverling, Lina
%A Stewart, Chip
%A Sültmann, Holger
%A Torrents, David
%A Tubio, Jose M C
%A Villasante, Izar
%A Waddell, Nicola
%A Wala, Jeremiah A
%A Weischenfeldt, Joachim
%A Yang, Lixing
%A Yao, Xiaotong
%A Yoon, Sung-Soo
%A Zamora, Jorge
%A Zhang, Cheng-Zhong
%T Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing.
%J Nature genetics
%V 52
%N 3
%@ 1546-1718
%C London
%I Macmillan Publishers Limited, part of Springer Nature
%M DKFZ-2020-00439
%P 331-341
%D 2020
%Z 2020 Mar;52(3):331-341 / In the version of this article initially published, author Peter J. Park had affiliation numbers 2 and 3; the correct affiliation numbers are1 and 2. The error has been corrected in the HTML and PDF versions of the article.
%X Chromothripsis is a mutational phenomenon characterized by massive, clustered genomic rearrangements that occurs in cancer and other diseases. Recent studies in selected cancer types have suggested that chromothripsis may be more common than initially inferred from low-resolution copy-number data. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), we analyze patterns of chromothripsis across 2,658 tumors from 38 cancer types using whole-genome sequencing data. We find that chromothripsis events are pervasive across cancers, with a frequency of more than 50
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32025003
%R 10.1038/s41588-019-0576-7
%U https://inrepo02.dkfz.de/record/153754