TY  - JOUR
AU  - Cortés-Ciriano, Isidro
AU  - Lee, Jake June-Koo
AU  - Xi, Ruibin
AU  - Jain, Dhawal
AU  - Jung, Youngsook L
AU  - Yang, Lixing
AU  - Gordenin, Dmitry
AU  - Klimczak, Leszek J
AU  - Zhang, Cheng-Zhong
AU  - Pellman, David S
AU  - Park, Peter J
AU  - Akdemir, Kadir C
AU  - Alvarez, Eva G
AU  - Baez-Ortega, Adrian
AU  - Beroukhim, Rameen
AU  - Boutros, Paul C
AU  - Bowtell, David D L
AU  - Brors, Benedikt
AU  - Burns, Kathleen H
AU  - Campbell, Peter J
AU  - Chan, Kin
AU  - Chen, Ken
AU  - Cortés-Ciriano, Isidro
AU  - Dueso-Barroso, Ana
AU  - Dunford, Andrew J
AU  - Edwards, Paul A
AU  - Estivill, Xavier
AU  - Etemadmoghadam, Dariush
AU  - Feuerbach, Lars
AU  - Fink, J Lynn
AU  - Frenkel-Morgenstern, Milana
AU  - Garsed, Dale W
AU  - Gerstein, Mark
AU  - Gordenin, Dmitry A
AU  - Haan, David
AU  - Haber, James E
AU  - Hess, Julian M
AU  - Hutter, Barbara
AU  - Imielinski, Marcin
AU  - Jones, David T W
AU  - Ju, Young Seok
AU  - Kazanov, Marat D
AU  - Klimczak, Leszek J
AU  - Koh, Youngil
AU  - Korbel, Jan O
AU  - Kumar, Kiran
AU  - Lee, Eunjung Alice
AU  - Lee, Jake June-Koo
AU  - Li, Yilong
AU  - Lynch, Andy G
AU  - Macintyre, Geoff
AU  - Markowetz, Florian
AU  - Martincorena, Iñigo
AU  - Martinez-Fundichely, Alexander
AU  - Miyano, Satoru
AU  - Nakagawa, Hidewaki
AU  - Navarro, Fabio C P
AU  - Ossowski, Stephan
AU  - Park, Peter J
AU  - Pearson, John V
AU  - Puiggròs, Montserrat
AU  - Rippe, Karsten
AU  - Roberts, Nicola D
AU  - Roberts, Steven A
AU  - Rodriguez-Martin, Bernardo
AU  - Schumacher, Steven E
AU  - Scully, Ralph
AU  - Shackleton, Mark
AU  - Sidiropoulos, Nikos
AU  - Sieverling, Lina
AU  - Stewart, Chip
AU  - Sültmann, Holger
AU  - Torrents, David
AU  - Tubio, Jose M C
AU  - Villasante, Izar
AU  - Waddell, Nicola
AU  - Wala, Jeremiah A
AU  - Weischenfeldt, Joachim
AU  - Yang, Lixing
AU  - Yao, Xiaotong
AU  - Yoon, Sung-Soo
AU  - Zamora, Jorge
AU  - Zhang, Cheng-Zhong
TI  - Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing.
JO  - Nature genetics
VL  - 52
IS  - 3
SN  - 1546-1718
CY  - London
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - DKFZ-2020-00439
SP  - 331-341
PY  - 2020
N1  - 2020 Mar;52(3):331-341 / In the version of this article initially published, author Peter J. Park had affiliation numbers 2 and 3; the correct affiliation numbers are1 and 2. The error has been corrected in the HTML and PDF versions of the article.
AB  - Chromothripsis is a mutational phenomenon characterized by massive, clustered genomic rearrangements that occurs in cancer and other diseases. Recent studies in selected cancer types have suggested that chromothripsis may be more common than initially inferred from low-resolution copy-number data. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), we analyze patterns of chromothripsis across 2,658 tumors from 38 cancer types using whole-genome sequencing data. We find that chromothripsis events are pervasive across cancers, with a frequency of more than 50
LB  - PUB:(DE-HGF)16
C6  - pmid:32025003
DO  - DOI:10.1038/s41588-019-0576-7
UR  - https://inrepo02.dkfz.de/record/153754
ER  -