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000153782 1001_ $$aKarrasch, Stefan$$b0
000153782 245__ $$a[Lung function in the German National Cohort: methods and initial results].
000153782 260__ $$aHeidelberg$$bSpringer$$c2020
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000153782 520__ $$aA nationwide assessment of the respiratory status on the basis of standardized lung function measurements has so far not been available in Germany. The present work describes the lung function tests in the German National Cohort (GNC) and presents initial results based on the GNC Midterm Baseline Dataset.The assessment of lung function in the GNC comprised spirometry (level 1) and the determination of exhaled nitric oxide (FeNO, level 2). Our quality assurance concept included regular training of lung function test procedures at various GNC sites, interim evaluations of test quality, as well as regular calibration/measurement checks of test equipment. For spirometry, we established a stepwise procedure for offline quality control based on raw flow volume curves.In the present dataset (n = 101,734), spirometry was available for 86,893 study participants and FeNO was available for 15,228 participants. The average (±SD) FEV1 Z score (according to GLI 2012) was -0.321 ± 1.047, the FVC Z score was -0.153 ± 0.941, and the FEV1/FVC Z score was -0.337 ± 0.901. The difference in FEV1/FVC between current smokers and never-smokers increased with age. The average FeNO was 14.2 ÷ 2.0 ppb. Current smoking reduced FeNO levels by 43%, whereas respiratory allergy increased FeNO levels by 16% in nonsmokers.The results of spirometry and the FeNO measurements are in the expected range with regard to their distributions and correlates. The GNC provides a valuable basis for future investigations of respiratory health and its determinants as well as research into the prevention of respiratory diseases in Germany.
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000153782 7001_ $$aPeters, Annette$$b1
000153782 7001_ $$aMeisinger, Christa$$b2
000153782 7001_ $$aFerland, Maike$$b3
000153782 7001_ $$aJaeschke, Lina$$b4
000153782 7001_ $$aPischon, Tobias$$b5
000153782 7001_ $$aFricke, Julia$$b6
000153782 7001_ $$aKeil, Thomas$$b7
000153782 7001_ $$aGastell, Sylvia$$b8
000153782 7001_ $$aSchulze, Matthias$$b9
000153782 7001_ $$aBrandes, Mirko$$b10
000153782 7001_ $$aGünther, Kathrin$$b11
000153782 7001_ $$aKuß, Oliver$$b12
000153782 7001_ $$aSchikowski, Tamara$$b13
000153782 7001_ $$aEmmel, Carina$$b14
000153782 7001_ $$aJöckel, Karl-Heinz$$b15
000153782 7001_ $$aMichels, Karin B$$b16
000153782 7001_ $$aFranzke, Claus-Werner$$b17
000153782 7001_ $$aLanger, Susan$$b18
000153782 7001_ $$aMikolajczyk, Rafael$$b19
000153782 7001_ $$aJagodzinski, Annika$$b20
000153782 7001_ $$aBecher, Heiko$$b21
000153782 7001_ $$aCastell, Stefanie$$b22
000153782 7001_ $$aKemmling, Yvonne$$b23
000153782 7001_ $$aWaniek, Sabina$$b24
000153782 7001_ $$aLieb, Wolfgang$$b25
000153782 7001_ $$aWirkner, Kerstin$$b26
000153782 7001_ $$aLoeffler, Markus$$b27
000153782 7001_ $$0P:(DE-He78)e0ac0d57cdb66d87f2d95ae5f6178c1b$$aGreiser, Karin Halina$$b28$$udkfz
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000153782 7001_ $$aLegath, Nicole$$b30
000153782 7001_ $$aBerger, Klaus$$b31
000153782 7001_ $$aSchipf, Sabine$$b32
000153782 7001_ $$aHoffmann, Wolfgang$$b33
000153782 7001_ $$aSedlmeier, Anja$$b34
000153782 7001_ $$aLeitzmann, Michael$$b35
000153782 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b36$$udkfz
000153782 7001_ $$aHolleczek, Bernd$$b37
000153782 7001_ $$aSchulz, Holger$$b38
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