TY  - JOUR
AU  - Karrasch, Stefan
AU  - Peters, Annette
AU  - Meisinger, Christa
AU  - Ferland, Maike
AU  - Jaeschke, Lina
AU  - Pischon, Tobias
AU  - Fricke, Julia
AU  - Keil, Thomas
AU  - Gastell, Sylvia
AU  - Schulze, Matthias
AU  - Brandes, Mirko
AU  - Günther, Kathrin
AU  - Kuß, Oliver
AU  - Schikowski, Tamara
AU  - Emmel, Carina
AU  - Jöckel, Karl-Heinz
AU  - Michels, Karin B
AU  - Franzke, Claus-Werner
AU  - Langer, Susan
AU  - Mikolajczyk, Rafael
AU  - Jagodzinski, Annika
AU  - Becher, Heiko
AU  - Castell, Stefanie
AU  - Kemmling, Yvonne
AU  - Waniek, Sabina
AU  - Lieb, Wolfgang
AU  - Wirkner, Kerstin
AU  - Loeffler, Markus
AU  - Greiser, Karin Halina
AU  - Kaaks, Rudolf
AU  - Legath, Nicole
AU  - Berger, Klaus
AU  - Schipf, Sabine
AU  - Hoffmann, Wolfgang
AU  - Sedlmeier, Anja
AU  - Leitzmann, Michael
AU  - Brenner, Hermann
AU  - Holleczek, Bernd
AU  - Schulz, Holger
TI  - [Lung function in the German National Cohort: methods and initial results].
JO  - Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
VL  - 63
IS  - 3
SN  - 1437-1588
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2020-00448
SP  - 322-331
PY  - 2020
N1  - 2020 Mar;63(3):322-331
AB  - A nationwide assessment of the respiratory status on the basis of standardized lung function measurements has so far not been available in Germany. The present work describes the lung function tests in the German National Cohort (GNC) and presents initial results based on the GNC Midterm Baseline Dataset.The assessment of lung function in the GNC comprised spirometry (level 1) and the determination of exhaled nitric oxide (FeNO, level 2). Our quality assurance concept included regular training of lung function test procedures at various GNC sites, interim evaluations of test quality, as well as regular calibration/measurement checks of test equipment. For spirometry, we established a stepwise procedure for offline quality control based on raw flow volume curves.In the present dataset (n = 101,734), spirometry was available for 86,893 study participants and FeNO was available for 15,228 participants. The average (±SD) FEV1 Z score (according to GLI 2012) was -0.321 ± 1.047, the FVC Z score was -0.153 ± 0.941, and the FEV1/FVC Z score was -0.337 ± 0.901. The difference in FEV1/FVC between current smokers and never-smokers increased with age. The average FeNO was 14.2 ÷ 2.0 ppb. Current smoking reduced FeNO levels by 43
LB  - PUB:(DE-HGF)16
C6  - pmid:32078705
DO  - DOI:10.1007/s00103-020-03102-1
UR  - https://inrepo02.dkfz.de/record/153782
ER  -