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@ARTICLE{Karrasch:153782,
      author       = {S. Karrasch and A. Peters and C. Meisinger and M. Ferland
                      and L. Jaeschke and T. Pischon and J. Fricke and T. Keil and
                      S. Gastell and M. Schulze and M. Brandes and K. Günther and
                      O. Kuß and T. Schikowski and C. Emmel and K.-H. Jöckel and
                      K. B. Michels and C.-W. Franzke and S. Langer and R.
                      Mikolajczyk and A. Jagodzinski and H. Becher and S. Castell
                      and Y. Kemmling and S. Waniek and W. Lieb and K. Wirkner and
                      M. Loeffler and K. H. Greiser$^*$ and R. Kaaks$^*$ and N.
                      Legath and K. Berger and S. Schipf and W. Hoffmann and A.
                      Sedlmeier and M. Leitzmann and H. Brenner$^*$ and B.
                      Holleczek and H. Schulz},
      title        = {[{L}ung function in the {G}erman {N}ational {C}ohort:
                      methods and initial results].},
      journal      = {Bundesgesundheitsblatt, Gesundheitsforschung,
                      Gesundheitsschutz},
      volume       = {63},
      number       = {3},
      issn         = {1437-1588},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2020-00448},
      pages        = {322-331},
      year         = {2020},
      note         = {2020 Mar;63(3):322-331},
      abstract     = {A nationwide assessment of the respiratory status on the
                      basis of standardized lung function measurements has so far
                      not been available in Germany. The present work describes
                      the lung function tests in the German National Cohort (GNC)
                      and presents initial results based on the GNC Midterm
                      Baseline Dataset.The assessment of lung function in the GNC
                      comprised spirometry (level 1) and the determination of
                      exhaled nitric oxide (FeNO, level 2). Our quality assurance
                      concept included regular training of lung function test
                      procedures at various GNC sites, interim evaluations of test
                      quality, as well as regular calibration/measurement checks
                      of test equipment. For spirometry, we established
                      a stepwise procedure for offline quality control based on
                      raw flow volume curves.In the present dataset
                      (n = 101,734), spirometry was available for 86,893 study
                      participants and FeNO was available for 15,228 participants.
                      The average (±SD) FEV1 Z score (according to GLI 2012) was
                      -0.321 ± 1.047, the FVC Z score was
                      -0.153 ± 0.941, and the FEV1/FVC Z score was
                      -0.337 ± 0.901. The difference in FEV1/FVC between
                      current smokers and never-smokers increased with age. The
                      average FeNO was 14.2 ÷ 2.0 ppb. Current smoking
                      reduced FeNO levels by $43\%,$ whereas respiratory allergy
                      increased FeNO levels by $16\%$ in nonsmokers.The results of
                      spirometry and the FeNO measurements are in the expected
                      range with regard to their distributions and correlates. The
                      GNC provides a valuable basis for future investigations of
                      respiratory health and its determinants as well as research
                      into the prevention of respiratory diseases in Germany.},
      cin          = {C020 / C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C070-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32078705},
      doi          = {10.1007/s00103-020-03102-1},
      url          = {https://inrepo02.dkfz.de/record/153782},
}