%0 Journal Article
%A Le Cornet, Charlotte
%A Walter, Britta
%A Sookthai, Disorn
%A Johnson, Theron S
%A Kühn, Tilman
%A Herpel, Ester
%A Kaaks, Rudolf
%A Turzanski-Fortner, Renée
%T Circulating 27-hydroxycholesterol and breast cancer tissue expression of CYP27A1, CYP7B1, LXR-β, and ERβ: results from the EPIC-Heidelberg cohort.
%J Breast cancer research
%V 22
%N 1
%@ 1465-542X
%C London
%I BioMed Central
%M DKFZ-2020-00454
%P 23
%D 2020
%Z #EA:C020#LA:C020#
%X Experimental and epidemiological studies demonstrate a role for 27-hydroxycholesterol (27HC) in breast cancer development, though results are conflicting. Cholesterol 27-hydroxylase (CYP27A1) and oxysterol 7-alpha-hydroxylase (CYP7B1) regulate 27HC concentrations, while differential expression of the liver X receptor (LXR) and estrogen receptor beta (ERβ) may impact the association between 27HC and breast cancer risk.We evaluated correlates of tumor tissue expression of CYP27A1, CYP7B1, LXR-β, and ERβ and the association between circulating prediagnostic 27HC concentrations and breast cancer risk by marker expression in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heidelberg cohort including 287 breast cancer cases with tumor tissue available. Tumor protein expression was evaluated using immunohistochemistry, and serum 27HC concentrations quantified using liquid chromatography-mass spectrometry. Conditional logistic regression models were used to estimate odds ratios (ORs) and 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32075687
%R 10.1186/s13058-020-1253-6
%U https://inrepo02.dkfz.de/record/153788