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@ARTICLE{LeCornet:153788,
      author       = {C. Le Cornet$^*$ and B. Walter and D. Sookthai$^*$ and T.
                      S. Johnson$^*$ and T. Kühn$^*$ and E. Herpel and R.
                      Kaaks$^*$ and R. Turzanski-Fortner$^*$},
      title        = {{C}irculating 27-hydroxycholesterol and breast cancer
                      tissue expression of {CYP}27{A}1, {CYP}7{B}1, {LXR}-β, and
                      {ER}β: results from the {EPIC}-{H}eidelberg cohort.},
      journal      = {Breast cancer research},
      volume       = {22},
      number       = {1},
      issn         = {1465-542X},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2020-00454},
      pages        = {23},
      year         = {2020},
      note         = {#EA:C020#LA:C020#},
      abstract     = {Experimental and epidemiological studies demonstrate a role
                      for 27-hydroxycholesterol (27HC) in breast cancer
                      development, though results are conflicting. Cholesterol
                      27-hydroxylase (CYP27A1) and oxysterol 7-alpha-hydroxylase
                      (CYP7B1) regulate 27HC concentrations, while differential
                      expression of the liver X receptor (LXR) and estrogen
                      receptor beta (ERβ) may impact the association between 27HC
                      and breast cancer risk.We evaluated correlates of tumor
                      tissue expression of CYP27A1, CYP7B1, LXR-β, and ERβ and
                      the association between circulating prediagnostic 27HC
                      concentrations and breast cancer risk by marker expression
                      in a nested case-control study within the European
                      Prospective Investigation into Cancer and Nutrition
                      (EPIC)-Heidelberg cohort including 287 breast cancer cases
                      with tumor tissue available. Tumor protein expression was
                      evaluated using immunohistochemistry, and serum 27HC
                      concentrations quantified using liquid chromatography-mass
                      spectrometry. Conditional logistic regression models were
                      used to estimate odds ratios (ORs) and $95\%$ confidence
                      intervals (CIs).A higher proportion of CYP7B1-positive cases
                      were progesterone receptor (PR)-positive, relative to
                      CYP7B1-negative cases, whereas a higher proportion of
                      ERβ-positive cases were Bcl-2 low, relative to
                      ERβ-negative cases. No differences in tumor tissue marker
                      positivity were observed by reproductive and lifestyle
                      factors. We observed limited evidence of heterogeneity in
                      associations between circulating 27HC and breast cancer risk
                      by tumor tissue expression of CYP27A1, CYP7B1, LXR-β, and
                      ERβ, with the exception of statistically significant
                      heterogeneity by LXR-β status in the subgroup of women
                      perimenopausal at blood collection (p = 0.02).This
                      exploratory study suggests limited associations between
                      tumor marker status and epidemiologic or breast cancer
                      characteristics. Furthermore, the association between
                      circulating 27HC and breast cancer risk may not vary by
                      tumor expression of CYP27A1, CYP7B1, LXR-β, or ERβ.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32075687},
      doi          = {10.1186/s13058-020-1253-6},
      url          = {https://inrepo02.dkfz.de/record/153788},
}