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@ARTICLE{Anusruti:153795,
      author       = {A. Anusruti$^*$ and Y. Xuan$^*$ and X. Gào$^*$ and E. H.
                      J. M. Jansen and D. C. Laetsch$^*$ and H. Brenner$^*$ and B.
                      Schöttker$^*$},
      title        = {{F}actors associated with high oxidative stress in patients
                      with type 2 diabetes: a meta-analysis of two cohort
                      studies.},
      journal      = {BMJ Open Diabetes Research $\&$ Care},
      volume       = {8},
      number       = {1},
      issn         = {2052-4897},
      address      = {London},
      publisher    = {BMJ Publishing Group},
      reportid     = {DKFZ-2020-00461},
      pages        = {e000933},
      year         = {2020},
      note         = {#EA:C070#LA:C070#},
      abstract     = {Our objective is to identify the potential factors
                      associated with serum Diacron's reactive oxygen metabolites
                      test (D-ROM) levels of patients with type 2 diabetes
                      mellitus (T2DM) by conducting cross-sectional and
                      longitudinal analyses in two large cohorts and further
                      strengthening these results by performing a
                      meta-analysis.Serum D-ROM concentrations were measured in
                      1045 and 1101 patients with T2DM from two independent cohort
                      studies from Germany at baseline and repeatedly 3-4 years
                      later. The cross-sectional and longitudinal associations of
                      various potential determinants with D-ROM levels were
                      assessed with a backwards selection algorithm in
                      multivariable adjusted models.In the meta-analysis of the
                      cross-sectional analysis, female sex, low education,
                      obesity, smoking, high total cholesterol, hemoglobin A1c
                      $≥7\%,$ no diabetes medication, a history of myocardial
                      infarction, heart failure, a history of cancer and C
                      reactive protein levels (CRP) >3 mg/L were statistically
                      significantly associated with increased D-ROM levels in
                      patients with T2DM. The meta-analysis of the longitudinal
                      analysis revealed that old age, female sex, obesity,
                      smoking, physical inactivity, high alcohol consumption, ≥5
                      years since diabetes diagnosis and CRP levels between 3 mg/L
                      and 10 mg/L were statistically significantly associated with
                      D-ROM levels measured 3-4 years later.This comprehensive
                      analysis confirmed that several modifiable risk factors are
                      being associated with oxidative stress in patients with T2DM
                      within an observational study design. We discuss potential
                      prevention measures against these risk factors that might
                      help to reduce oxidative stress and to prevent some cases of
                      premature mortality in patients with T2DM.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
      pid          = {G:(DE-HGF)POF3-323},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32079612},
      doi          = {10.1136/bmjdrc-2019-000933},
      url          = {https://inrepo02.dkfz.de/record/153795},
}