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@ARTICLE{Phipps:153797,
      author       = {A. I. Phipps and E. Alwers$^*$ and T. Harrison and B.
                      Banbury and H. Brenner$^*$ and P. T. Campbell and J.
                      Chang-Claude$^*$ and D. Buchanan and A. T. Chan and A. B.
                      Farris and J. C. Figueiredo and S. Gallinger and G. G. Giles
                      and M. Jenkins and R. L. Milne and P. A. Newcomb and M. L.
                      Slattery and M. Song and S. Ogino and S. H. Zaidi and M.
                      Hoffmeister$^*$ and U. Peters},
      title        = {{A}ssociation {B}etween {M}olecular {S}ubtypes of
                      {C}olorectal {T}umors and {P}atient {S}urvival, {B}ased on
                      {P}ooled {A}nalysis of 7 {I}nternational {S}tudies.},
      journal      = {Gastroenterology},
      volume       = {158},
      number       = {8},
      issn         = {0016-5085},
      address      = {Philadelphia, Pa. [u.a.]},
      publisher    = {Saunders},
      reportid     = {DKFZ-2020-00463},
      pages        = {2158-2168.e4},
      year         = {2020},
      note         = {2020 Jun;158(8):2158-2168.e4 / #EA:C070#LA:C070#},
      abstract     = {The heterogeneity among colorectal tumors is probably due
                      to differences in developmental pathways and might associate
                      with patient survival times. We studied the relationship
                      among markers of different subtypes of colorectal tumors and
                      patient survival.We pooled data from 7 observational
                      studies, comprising 5010 patients with colorectal cancer.
                      All the studies collected information on microsatellite
                      instability (MSI), CpG island methylator phenotype (CIMP),
                      and mutations in KRAS and BRAF in tumors. Tumors with
                      complete marker data were classified as type 1 (MSI high,
                      CIMP positive, with pathogenic mutations in BRAF but not
                      KRAS), type 2 (not MSI high, CIMP positive, with pathogenic
                      mutations in BRAF but not KRAS); type 3 (not MSI high or
                      CIMP, with pathogenic mutations in KRAS but not BRAF); type
                      4 (not MSI-high or CIMP, no pathogenic mutations in BRAF or
                      KRAS), or type 5 (MSI-high, no CIMP, no pathogenic mutations
                      in BRAF or KRAS). We used Cox regression to estimate hazard
                      ratios (HR) and $95\%$ CIs for associations of these
                      subtypes and tumor markers with disease-specific survival
                      (DSS) and overall survival (OS) times, adjusting for age,
                      sex, stage at diagnosis, and study population.Patients with
                      type 2 colorectal tumors had significantly longer time of
                      DSS than patients with type 4 tumors (HRDSS, 1.66; $95\%$
                      CI, 1.33-2.07), regardless of sex, age, or stage at
                      diagnosis. Patients without MSI-high tumors had
                      significantly shorter time of DSS compared to patients with
                      MSI-high tumors (HRDSS, 0.42; $95\%$ CI, 0.27-0.64),
                      regardless of other tumor markers or stage, or patient sex
                      or age.In a pooled analysis of data from 7 observational
                      studies of patients with colorectal cancer, we found that
                      tumor subtypes, defined by combinations of 4 common tumor
                      markers, were associated with differences in survival time.
                      Colorectal tumor subtypes might therefore be used in
                      determining patients' prognoses.},
      cin          = {C070 / C120 / HD01 / C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32088204},
      doi          = {10.1053/j.gastro.2020.02.029},
      url          = {https://inrepo02.dkfz.de/record/153797},
}