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@ARTICLE{Mllers:153852,
      author       = {T. Möllers$^*$ and L. Perna$^*$ and H. Stocker$^*$ and P.
                      Ihle and I. Schubert and B. Schöttker$^*$ and L. Frölich
                      and H. Brenner$^*$},
      title        = {{N}ew use of psychotropic medication after hospitalization
                      among people with dementia.},
      journal      = {International journal of geriatric psychiatry},
      volume       = {35},
      number       = {6},
      issn         = {1099-1166},
      address      = {Chichester [u.a.]},
      publisher    = {Wiley},
      reportid     = {DKFZ-2020-00470},
      pages        = {640-649},
      year         = {2020},
      note         = {2020 Jun;35(6):640-649#EA:C070#LA:C070#},
      abstract     = {Psychotropic medication is commonly used among people with
                      dementia (PWD), but it shows modest efficacy and it has been
                      associated with severe adverse events. Hospitalizations are
                      an opportunity for medication management as well as
                      treatment recommendations for outpatient physicians. The aim
                      of this study was to asses factors associated with new use
                      of psychotropic medication after hospitalization among
                      PWD.We conducted a retrospective dynamic cohort study from
                      2004 to 2015 using claims data from a German health
                      insurance company. PWD were identified by an algorithm that
                      included ICD-10 diagnosis and diagnostic measures. The
                      medication classes included were antidepressants,
                      antipsychotics, anxiolytics or hypnotics/sedatives, and
                      Alzheimer‧s medication. The assessment period was up to
                      30 days after discharge from the hospital across four
                      hospitalizations.The main predictors for new use of
                      psychotropic medication were similar across medication
                      classes. Neuropsychiatric symptoms (NPS) and the need of
                      care were associated with higher odds of new use of
                      antidepressants, antipsychotics, and anxiolytics or
                      hypnotics/sedatives. A hospital stay due to dementia was an
                      independent predictor for new use across medication classes
                      as well. Delirium increased the odds for new use of
                      antipsychotics and anxiolytics or
                      hypnotics/sedatives.Factors associated with new use of
                      psychotropic medication included delirium, NPS, and the need
                      of care in PWD. The findings highlight the need for
                      preventive interventions and non-medical treatment options
                      in regards to delirium and NPS as well as for a more
                      intensive use of screening tools for inappropriate
                      medication use among PWD. This article is protected by
                      copyright. All rights reserved.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32100308},
      doi          = {10.1002/gps.5282},
      url          = {https://inrepo02.dkfz.de/record/153852},
}