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@ARTICLE{Peukert:153919,
      author       = {X. Peukert$^*$ and K. Steindorf$^*$ and S. B. Schagen and
                      A. Runz and P. Meyer and P. Zimmer$^*$},
      title        = {{H}ippocampus-{R}elated {C}ognitive and {A}ffective
                      {I}mpairments in {P}atients {W}ith {B}reast {C}ancer-{A}
                      {S}ystematic {R}eview.},
      journal      = {Frontiers in oncology},
      volume       = {10},
      issn         = {2234-943X},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DKFZ-2020-00529},
      pages        = {147},
      year         = {2020},
      note         = {#EA:C110#LA:C110#},
      abstract     = {Background: Although improvements in medical treatment lead
                      to a steadily rising survival rate of breast cancer patients
                      (BCP), it is associated with a decrease in cognitive and
                      affective function. The hippocampus, a brain region with a
                      high influence on both cognitive and affective function, is
                      increasingly becoming the focus of current research because
                      of its high vulnerability to adverse direct
                      (chemotherapeutic agents, endocrine therapeutic agents, and
                      radiation) or indirect (stress and other psycho-social
                      factors) treatment-related effects. Methods: This systematic
                      review analyses current data from literature combining
                      hippocampus-related brain changes due to breast cancer
                      treatment with associated cancer-related cognitive and
                      affective impairments (CRCI/CRAI). The seven studies that
                      met the inclusion criteria consisted of six cross-sectional
                      studies and one longitudinal study. Results: The study
                      results indicate hippocampal differences across all types of
                      treatment. Those differences include volume loss,
                      deformation, and changes in functional connectivity. They
                      are associated with CRCI, revealing executive function as
                      well as working memory, episodic memory, and prospective
                      memory as the most affected domains. Although an interaction
                      between hippocampus-related brain changes, CRCI, and CRAI
                      can be hypothesized, CRAI are less reflected in current
                      research. Discussion: More research including longitudinal
                      assessments with better overall methodology is needed to
                      fully understand the interaction between hippocampal
                      alterations and both CRCI and CRAI due to breast cancer
                      treatment.},
      subtyp        = {Review Article},
      cin          = {C110},
      ddc          = {610},
      cid          = {I:(DE-He78)C110-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32154164},
      pmc          = {pmc:PMC7046686},
      doi          = {10.3389/fonc.2020.00147},
      url          = {https://inrepo02.dkfz.de/record/153919},
}