TY  - JOUR
AU  - Katzke, Verena
AU  - Johnson, Theron
AU  - Sookthai, Disorn
AU  - Hüsing, Anika
AU  - Kühn, Tilman
AU  - Kaaks, Rudolf
TI  - Circulating liver enzymes and risks of chronic diseases and mortality in the prospective EPIC-Heidelberg case-cohort study.
JO  - BMJ open
VL  - 10
IS  - 3
SN  - 2044-6055
CY  - London
PB  - BMJ Publishing Group
M1  - DKFZ-2020-00532
SP  - e033532
PY  - 2020
N1  - #EA:C020#LA:C020#
AB  - Elevated liver enzyme concentrations in blood are indicative of liver diseases and may provide an early signal for being at risk for other chronic diseases. Our study aimed to assess the relationships of alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), alanine aminotransferase (ALT), aspartate transaminase (AST) and the De Ritis ratio (AST/ALT) with incidence and mortality of cardiovascular diseases (CVD) and the four most common cancers, that is, breast, prostate, colorectal and lung.We analysed a case-cohort sample of the prospective European Prospective Investigation into Cancer and Nutrition-Heidelberg cohort, including cancer (n=1632), cancer mortality (n=761), CVD (n=1070), CVD mortality (n=381) and a random subcohort (n=2739) with an average follow-up duration of 15.6 years. Concentrations of liver enzymes were measured in prediagnostic blood samples and Prentice-weighted Cox regression models were used to estimate HRs with 95
LB  - PUB:(DE-HGF)16
C6  - pmid:32152162
DO  - DOI:10.1136/bmjopen-2019-033532
UR  - https://inrepo02.dkfz.de/record/153922
ER  -