%0 Journal Article
%A Carr, Prudence
%A Weigl, Korbinian
%A Edelmann, Dominic
%A Jansen, Lina
%A Chang-Claude, Jenny
%A Brenner, Hermann
%A Hoffmeister, Michael
%T Estimation of Absolute Risk of Colorectal Cancer Based on Healthy Lifestyle, Genetic Risk, and Colonoscopy Status in a Population-based Study.
%J Gastroenterology
%V 159
%N 1
%@ 0016-5085
%C Philadelphia, Pa. [u.a.]
%I Saunders
%M DKFZ-2020-00579
%P 129-138.e9
%D 2020
%Z 2020 Jul;159(1):129-138.e9#EA:C070#LA:C070#
%X Estimates of absolute risk of colorectal cancer (CRC) are needed to facilitate communication and better inform the public about the potentials and limits of cancer prevention.Using data from a large population-based case-control study in Germany (DACHS study, which began in 2003) and population registry data, we calculated 30-year absolute risk estimates for development of CRC, based on a healthy lifestyle score (derived from 5 modifiable lifestyle factors: smoking, alcohol consumption, diet, physical activity, and body fatness), a polygenic risk score (based on 90 single nucleotide polymorphisms), and colonoscopy history.We analyzed data from 4220 patients with CRC and 3338 individuals without CRC. Adherence to a healthy lifestyle and colonoscopy in the preceding 10 y were associated with a reduced relative risk of CRC in men and women. We observed a higher CRC risk in participants with high or intermediate genetic risk scores. For 50-year-old men and women without a colonoscopy, the absolute risk of CRC varied according to the polygenic risk score and the healthy lifestyle score (men, 3.5
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32179093
%R 10.1053/j.gastro.2020.03.016
%U https://inrepo02.dkfz.de/record/154118