TY  - JOUR
AU  - Carr, Prudence
AU  - Weigl, Korbinian
AU  - Edelmann, Dominic
AU  - Jansen, Lina
AU  - Chang-Claude, Jenny
AU  - Brenner, Hermann
AU  - Hoffmeister, Michael
TI  - Estimation of Absolute Risk of Colorectal Cancer Based on Healthy Lifestyle, Genetic Risk, and Colonoscopy Status in a Population-based Study.
JO  - Gastroenterology
VL  - 159
IS  - 1
SN  - 0016-5085
CY  - Philadelphia, Pa. [u.a.]
PB  - Saunders
M1  - DKFZ-2020-00579
SP  - 129-138.e9
PY  - 2020
N1  - 2020 Jul;159(1):129-138.e9#EA:C070#LA:C070#
AB  - Estimates of absolute risk of colorectal cancer (CRC) are needed to facilitate communication and better inform the public about the potentials and limits of cancer prevention.Using data from a large population-based case-control study in Germany (DACHS study, which began in 2003) and population registry data, we calculated 30-year absolute risk estimates for development of CRC, based on a healthy lifestyle score (derived from 5 modifiable lifestyle factors: smoking, alcohol consumption, diet, physical activity, and body fatness), a polygenic risk score (based on 90 single nucleotide polymorphisms), and colonoscopy history.We analyzed data from 4220 patients with CRC and 3338 individuals without CRC. Adherence to a healthy lifestyle and colonoscopy in the preceding 10 y were associated with a reduced relative risk of CRC in men and women. We observed a higher CRC risk in participants with high or intermediate genetic risk scores. For 50-year-old men and women without a colonoscopy, the absolute risk of CRC varied according to the polygenic risk score and the healthy lifestyle score (men, 3.5
LB  - PUB:(DE-HGF)16
C6  - pmid:32179093
DO  - DOI:10.1053/j.gastro.2020.03.016
UR  - https://inrepo02.dkfz.de/record/154118
ER  -