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| 001 | 154118 | ||
| 005 | 20240229123056.0 | ||
| 024 | 7 | _ | |a 10.1053/j.gastro.2020.03.016 |2 doi |
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| 100 | 1 | _ | |a Carr, Prudence |0 P:(DE-He78)7d7ee36ed0313bbc4c91bc3df5950107 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Estimation of Absolute Risk of Colorectal Cancer Based on Healthy Lifestyle, Genetic Risk, and Colonoscopy Status in a Population-based Study. |
| 260 | _ | _ | |a Philadelphia, Pa. [u.a.] |c 2020 |b Saunders |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 500 | _ | _ | |a 2020 Jul;159(1):129-138.e9#EA:C070#LA:C070# |
| 520 | _ | _ | |a Estimates of absolute risk of colorectal cancer (CRC) are needed to facilitate communication and better inform the public about the potentials and limits of cancer prevention.Using data from a large population-based case-control study in Germany (DACHS study, which began in 2003) and population registry data, we calculated 30-year absolute risk estimates for development of CRC, based on a healthy lifestyle score (derived from 5 modifiable lifestyle factors: smoking, alcohol consumption, diet, physical activity, and body fatness), a polygenic risk score (based on 90 single nucleotide polymorphisms), and colonoscopy history.We analyzed data from 4220 patients with CRC and 3338 individuals without CRC. Adherence to a healthy lifestyle and colonoscopy in the preceding 10 y were associated with a reduced relative risk of CRC in men and women. We observed a higher CRC risk in participants with high or intermediate genetic risk scores. For 50-year-old men and women without a colonoscopy, the absolute risk of CRC varied according to the polygenic risk score and the healthy lifestyle score (men, 3.5%-13.4% and women, 2.5%-10.6%). For 50-year-old men and women with a colonoscopy, the absolute risk of developing CRC was much lower but still varied according to the polygenic risk score and the healthy lifestyle score (men, 1.2%-4.8% and women, 0.9%-4.2%). Among all risk factor profiles, the 30-y absolute risk estimates consistently decreased with adherence to a healthy lifestyle.In a population-based study, we found that a colonoscopy can drastically reduce the absolute risk of CRC and that the genetically predetermined risk of CRC can be further reduced by adherence to a healthy lifestyle. Our results show the magnitude of CRC prevention possible through colonoscopy and lifestyle at a predefined genetic risk. |
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| 700 | 1 | _ | |a Hoffmeister, Michael |0 P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f |b 6 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1053/j.gastro.2020.03.016 |g p. S0016508520303371 |0 PERI:(DE-600)1478699-0 |n 1 |p 129-138.e9 |t Gastroenterology |v 159 |y 2020 |x 0016-5085 |
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