TY  - JOUR
AU  - Neumeyer, Sonja Maria
AU  - Butterbach, Katja
AU  - Banbury, Barbara L
AU  - Berndt, Sonja I
AU  - Campbell, Peter T
AU  - Chlebowski, Rowan T
AU  - Chan, Andrew T
AU  - Giovannucci, Edward L
AU  - Joshi, Amit D
AU  - Ogino, Shuji
AU  - Song, Mingyang
AU  - McCullough, Marjorie L
AU  - Maalmi, Haifa
AU  - Manson, JoAnn E
AU  - Sakoda, Lori C
AU  - Schoen, Robert E
AU  - Slattery, Martha L
AU  - White, Emily
AU  - Win, Aung K
AU  - Figueiredo, Jane C
AU  - Hopper, John L
AU  - Macrae, Finlay A
AU  - Peters, Ulrike
AU  - Brenner, Hermann
AU  - Hoffmeister, Michael
AU  - Newcomb, Polly A
AU  - Chang-Claude, Jenny
TI  - Genetic predictors of circulating 25-hydroxyvitamin D and prognosis after colorectal cancer.
JO  - Cancer epidemiology, biomarkers & prevention
VL  - 29
IS  - 6
SN  - 1538-7755
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2020-00628
SP  - 1128-1134
PY  - 2020
N1  - 2020 Jun;29(6):1128-1134#EA:C020#LA:C020#
AB  - Low serum 25-hydroxyvitamin D (25(OH)D) concentrations in colorectal cancer (CRC) patients have been consistently associated with higher mortality in observational studies. It is unclear whether low 25(OH)D levels directly influence CRC mortality. To minimize bias, we use genetic variants associated with vitamin D levels to evaluate the association with overall and CRC-specific survival.Six genetic variants have been robustly identified to be associated with 25(OH)D levels in genome-wide association studies. Based on data from the International Survival Analysis in Colorectal Cancer Consortium (ISACC) the individual genetic variants and a weighted genetic risk score were tested for association with overall and CRC-specific survival using Cox proportional hazards models in 7 657 stage I-IV CRC patients of which 2 438 died from any cause and 1 648 died from CRC.The 25(OH)D decreasing allele of single nucleotide polymorphism (SNP) rs2282679 (GC) was associated with poorer CRC-specific survival, although not significant after multiple-testing correction. None of the other five SNPs showed an association. The genetic risk score showed non-significant associations with increased overall (HR=1.54, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:32188599
DO  - DOI:10.1158/1055-9965.EPI-19-1409
UR  - https://inrepo02.dkfz.de/record/154169
ER  -