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@ARTICLE{Neumeyer:154169,
      author       = {S. M. Neumeyer$^*$ and K. Butterbach$^*$ and B. L. Banbury
                      and S. I. Berndt and P. T. Campbell and R. T. Chlebowski and
                      A. T. Chan and E. L. Giovannucci and A. D. Joshi and S.
                      Ogino and M. Song and M. L. McCullough and H. Maalmi and J.
                      E. Manson and L. C. Sakoda and R. E. Schoen and M. L.
                      Slattery and E. White and A. K. Win and J. C. Figueiredo and
                      J. L. Hopper and F. A. Macrae and U. Peters and H.
                      Brenner$^*$ and M. Hoffmeister$^*$ and P. A. Newcomb and J.
                      Chang-Claude$^*$},
      title        = {{G}enetic predictors of circulating 25-hydroxyvitamin {D}
                      and prognosis after colorectal cancer.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {29},
      number       = {6},
      issn         = {1538-7755},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2020-00628},
      pages        = {1128-1134},
      year         = {2020},
      note         = {2020 Jun;29(6):1128-1134#EA:C020#LA:C020#},
      abstract     = {Low serum 25-hydroxyvitamin D (25(OH)D) concentrations in
                      colorectal cancer (CRC) patients have been consistently
                      associated with higher mortality in observational studies.
                      It is unclear whether low 25(OH)D levels directly influence
                      CRC mortality. To minimize bias, we use genetic variants
                      associated with vitamin D levels to evaluate the association
                      with overall and CRC-specific survival.Six genetic variants
                      have been robustly identified to be associated with 25(OH)D
                      levels in genome-wide association studies. Based on data
                      from the International Survival Analysis in Colorectal
                      Cancer Consortium (ISACC) the individual genetic variants
                      and a weighted genetic risk score were tested for
                      association with overall and CRC-specific survival using Cox
                      proportional hazards models in 7 657 stage I-IV CRC patients
                      of which 2 438 died from any cause and 1 648 died from
                      CRC.The 25(OH)D decreasing allele of single nucleotide
                      polymorphism (SNP) rs2282679 (GC) was associated with poorer
                      CRC-specific survival, although not significant after
                      multiple-testing correction. None of the other five SNPs
                      showed an association. The genetic risk score showed
                      non-significant associations with increased overall
                      (HR=1.54, $95\%$ CI:0.86-2.78) and CRC-specific mortality
                      (HR=1.76, $95\%$ CI:0.86-3.58). A significant increased risk
                      of overall mortality was observed in women (HR=3.26, $95\%$
                      CI:1.45-7.33, p-value for heterogeneity=0.01) and
                      normal-weight individuals (HR=4.14, $95\%$ CI:1.50-11.43,
                      p-value for heterogeneity=0.02).Our results provided little
                      evidence for an association of genetic predisposition of
                      lower vitamin D levels with increased overall or
                      CRC-specific survival, although power might have been an
                      issue.Further studies are warranted to investigate the
                      association in specific subgroups.},
      cin          = {C020 / C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)C120-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32188599},
      doi          = {10.1158/1055-9965.EPI-19-1409},
      url          = {https://inrepo02.dkfz.de/record/154169},
}