TY  - JOUR
AU  - Schaller-Paule, Martin A
AU  - Foerch, Christian
AU  - Kluge, Sara
AU  - Baumgarten, Peter
AU  - Konczalla, Jürgen
AU  - Steinbach, Joachim P
AU  - Wagner, Marlies
AU  - Luger, Anna-Luisa
TI  - Delayed Occurrence of Hypertrophic Olivary Degeneration after Therapy of Posterior Fossa Tumors: A Single Institution Retrospective Analysis.
JO  - Journal of Clinical Medicine
VL  - 8
IS  - 12
SN  - 2077-0383
CY  - Basel
PB  - MDPI
M1  - DKFZ-2020-00644
SP  - 2222 
PY  - 2019
AB  - (1) Background: A lesion within the dentato-rubro-olivary pathway (DROP) in the posterior fossa can cause secondary neurodegeneration of the inferior olivary nucleus: so-called hypertrophic olivary degeneration (HOD). The clinical syndrome of HOD occurs slowly over months and may be overlooked in progressive neuro-oncological diseases. Posterior fossa tumors are often located near these strategic structures. The goal of this study was to analyze the systematics of HOD occurrence in neuro-oncological patients. (2) Methods: The neuroradiological database of the university healthcare center was scanned for HOD-related terms from 2010 to 2019. After excluding patients with other causes of HOD, 12 datasets from neuro-oncological patients were analyzed under predetermined criteria. (3) Results: Patients received multimodal tumor treatments including neurosurgery, radiotherapy, and chemotherapy. HOD occurred both unilaterally (left n = 4; right n = 5) and bilaterally (n = 3). Though the mass effect of posterior fossa tumors had already affected strategic structures of the DROP, none of the patients showed signs of HOD on MRI until therapeutic measures including neurosurgery affecting the DROP were applied. HOD was visible on MRI within a median of 6 months after the neurosurgical intervention. In 67
LB  - PUB:(DE-HGF)16
C6  - pmid:31888178
C2  - pmc:PMC6947510
DO  - DOI:10.3390/jcm8122222
UR  - https://inrepo02.dkfz.de/record/154187
ER  -