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@ARTICLE{SchallerPaule:154187,
      author       = {M. A. Schaller-Paule and C. Foerch and S. Kluge and P.
                      Baumgarten and J. Konczalla and J. P. Steinbach$^*$ and M.
                      Wagner and A.-L. Luger$^*$},
      title        = {{D}elayed {O}ccurrence of {H}ypertrophic {O}livary
                      {D}egeneration after {T}herapy of {P}osterior {F}ossa
                      {T}umors: {A} {S}ingle {I}nstitution {R}etrospective
                      {A}nalysis.},
      journal      = {Journal of Clinical Medicine},
      volume       = {8},
      number       = {12},
      issn         = {2077-0383},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2020-00644},
      pages        = {2222},
      year         = {2019},
      abstract     = {(1) Background: A lesion within the dentato-rubro-olivary
                      pathway (DROP) in the posterior fossa can cause secondary
                      neurodegeneration of the inferior olivary nucleus: so-called
                      hypertrophic olivary degeneration (HOD). The clinical
                      syndrome of HOD occurs slowly over months and may be
                      overlooked in progressive neuro-oncological diseases.
                      Posterior fossa tumors are often located near these
                      strategic structures. The goal of this study was to analyze
                      the systematics of HOD occurrence in neuro-oncological
                      patients. (2) Methods: The neuroradiological database of the
                      university healthcare center was scanned for HOD-related
                      terms from 2010 to 2019. After excluding patients with other
                      causes of HOD, 12 datasets from neuro-oncological patients
                      were analyzed under predetermined criteria. (3) Results:
                      Patients received multimodal tumor treatments including
                      neurosurgery, radiotherapy, and chemotherapy. HOD occurred
                      both unilaterally (left n = 4; right n = 5) and bilaterally
                      (n = 3). Though the mass effect of posterior fossa tumors
                      had already affected strategic structures of the DROP, none
                      of the patients showed signs of HOD on MRI until therapeutic
                      measures including neurosurgery affecting the DROP were
                      applied. HOD was visible on MRI within a median of 6 months
                      after the neurosurgical intervention. In $67\%,$ the
                      presumed underlying surgical lesion in the DROP lay in the
                      contralateral dentate nucleus. (4) Conclusion: In a selected
                      cohort of neuro-oncological patients, therapeutic lesions
                      within the DROP were associated with HOD occurrence.},
      cin          = {L501},
      ddc          = {610},
      cid          = {I:(DE-He78)L501-20160331},
      pnm          = {899 - ohne Topic (POF3-899)},
      pid          = {G:(DE-HGF)POF3-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31888178},
      pmc          = {pmc:PMC6947510},
      doi          = {10.3390/jcm8122222},
      url          = {https://inrepo02.dkfz.de/record/154187},
}