TY  - JOUR
AU  - Xia, Zhiyu
AU  - Su, Yu-Ru
AU  - Petersen, Paneen
AU  - Qi, Lihong
AU  - Kim, Andre E
AU  - }, , USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
AU  - Figueiredo, Jane C
AU  - }, , USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. | Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
AU  - Lin, Yi
AU  - Nan, Hongmei
AU  - Sakoda, Lori C
AU  - Albanes, Demetrius
AU  - Berndt, Sonja I
AU  - Bézieau, Stéphane
AU  - Bien, Stephanie
AU  - Buchanan, Daniel D
AU  - Casey, Graham
AU  - Chan, Andrew T
AU  - Conti, David V
AU  - }, , USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
AU  - Drew, David A
AU  - Gallinger, Steven J
AU  - Gauderman, W James
AU  - }, , USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
AU  - Giles, Graham G
AU  - Gruber, Stephen B
AU  - }, , USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
AU  - Gunter, Marc J
AU  - Hoffmeister, Michael
AU  - Jenkins, Mark A
AU  - Joshi, Amit D
AU  - Le Marchand, Loic
AU  - Lewinger, Juan P
AU  - }, , USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
AU  - Li, Li
AU  - Lindor, Noralane M
AU  - Moreno, Victor
AU  - Murphy, Neil
AU  - Nassir, Rami
AU  - Newcomb, Polly A
AU  - Ogino, Shuji
AU  - Rennert, Gad
AU  - Song, Mingyang
AU  - Wang, Xiaoliang
AU  - Wolk, Alicja
AU  - Woods, Michael O
AU  - Brenner, Hermann
AU  - White, Emily
AU  - Slattery, Martha L
AU  - Giovannucci, Edward L
AU  - Chang-Claude, Jenny
AU  - Pharoah, Paul D P
AU  - Hsu, Li
AU  - Campbell, Peter T
AU  - Peters, Ulrike
TI  - Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk.
JO  - Cancer medicine
VL  - 9
IS  - 10
SN  - 2045-7634
CY  - Hoboken, NJ
PB  - Wiley
M1  - DKFZ-2020-00649
SP  - 3563-3573
PY  - 2020
N1  - 2020 May;9(10):3563-3573
AB  - Body mass index (BMI) and diabetes are established risk factors for colorectal cancer (CRC), likely through perturbations in metabolic traits (e.g. insulin resistance and glucose homeostasis). Identification of interactions between variation in genes and these metabolic risk factors may identify novel biologic insights into CRC etiology.To improve statistical power and interpretation for gene-environment interaction (G × E) testing, we tested genetic variants that regulate expression of a gene together for interaction with BMI (kg/m2 ) and diabetes on CRC risk among 26 017 cases and 20 692 controls. Each variant was weighted based on PrediXcan analysis of gene expression data from colon tissue generated in the Genotype-Tissue Expression Project for all genes with heritability ≥1
LB  - PUB:(DE-HGF)16
C6  - pmid:32207560
DO  - DOI:10.1002/cam4.2971
UR  - https://inrepo02.dkfz.de/record/154193
ER  -