%0 Journal Article
%A Amitay, Efrat
%A Carr, Prudence R
%A Jansen, Lina
%A Roth, Wilfried
%A Alwers, Elizabeth
%A Herpel, Esther
%A Kloor, Matthias
%A Bläker, Hendrik
%A Chang-Claude, Jenny
%A Brenner, Hermann
%A Hoffmeister, Michael
%T Smoking, alcohol consumption and colorectal cancer risk by molecular pathological subtypes and pathways.
%J British journal of cancer
%V 122
%N 11
%@ 1532-1827
%C Edinburgh
%I Nature Publ. Group
%M DKFZ-2020-00703
%P 1604-1610
%D 2020
%Z 2020 May;122(11):1604-1610#EA:C070#LA:C070#
%X Smoking and alcohol increase risk for colorectal malignancies. However, colorectal cancer (CRC) is a heterogenic disease and associations with the molecular pathological pathways are unclear.This population-based case-control study includes 2444 cases with first-diagnosis CRC and 2475 controls. Tumour tissue was analysed for MSI (microsatellite instability), CIMP (CpG island methylator phenotype), BRAF (B-Raf proto-oncogene serine/threonine kinase gene) and KRAS (Kirsten rat sarcoma viral oncogene homologue gene) mutations. Odds ratios (ORs) and 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32225169
%R 10.1038/s41416-020-0803-0
%U https://inrepo02.dkfz.de/record/154276