TY  - JOUR
AU  - Amitay, Efrat
AU  - Carr, Prudence R
AU  - Jansen, Lina
AU  - Roth, Wilfried
AU  - Alwers, Elizabeth
AU  - Herpel, Esther
AU  - Kloor, Matthias
AU  - Bläker, Hendrik
AU  - Chang-Claude, Jenny
AU  - Brenner, Hermann
AU  - Hoffmeister, Michael
TI  - Smoking, alcohol consumption and colorectal cancer risk by molecular pathological subtypes and pathways.
JO  - British journal of cancer
VL  - 122
IS  - 11
SN  - 1532-1827
CY  - Edinburgh
PB  - Nature Publ. Group
M1  - DKFZ-2020-00703
SP  - 1604-1610
PY  - 2020
N1  - 2020 May;122(11):1604-1610#EA:C070#LA:C070#
AB  - Smoking and alcohol increase risk for colorectal malignancies. However, colorectal cancer (CRC) is a heterogenic disease and associations with the molecular pathological pathways are unclear.This population-based case-control study includes 2444 cases with first-diagnosis CRC and 2475 controls. Tumour tissue was analysed for MSI (microsatellite instability), CIMP (CpG island methylator phenotype), BRAF (B-Raf proto-oncogene serine/threonine kinase gene) and KRAS (Kirsten rat sarcoma viral oncogene homologue gene) mutations. Odds ratios (ORs) and 95
LB  - PUB:(DE-HGF)16
C6  - pmid:32225169
DO  - DOI:10.1038/s41416-020-0803-0
UR  - https://inrepo02.dkfz.de/record/154276
ER  -