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| 001 | 154276 | ||
| 005 | 20240229123059.0 | ||
| 024 | 7 | _ | |a 10.1038/s41416-020-0803-0 |2 doi |
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| 024 | 7 | _ | |a 0007-0920 |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2020-00703 |
| 041 | _ | _ | |a eng |
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| 100 | 1 | _ | |a Amitay, Efrat |0 P:(DE-He78)6e02c183f41e45a5867dec393fb4616a |b 0 |e First author |
| 245 | _ | _ | |a Smoking, alcohol consumption and colorectal cancer risk by molecular pathological subtypes and pathways. |
| 260 | _ | _ | |a Edinburgh |c 2020 |b Nature Publ. Group |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1608627749_27035 |2 PUB:(DE-HGF) |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2020 May;122(11):1604-1610#EA:C070#LA:C070# |
| 520 | _ | _ | |a Smoking and alcohol increase risk for colorectal malignancies. However, colorectal cancer (CRC) is a heterogenic disease and associations with the molecular pathological pathways are unclear.This population-based case-control study includes 2444 cases with first-diagnosis CRC and 2475 controls. Tumour tissue was analysed for MSI (microsatellite instability), CIMP (CpG island methylator phenotype), BRAF (B-Raf proto-oncogene serine/threonine kinase gene) and KRAS (Kirsten rat sarcoma viral oncogene homologue gene) mutations. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated for associations between alcohol and smoking and CRC molecular subtypes and pathways.Current smoking showed higher ORs for MSI-high (OR = 2.79, 95% CI: 1.86-4.18) compared to MSS (OR = 1.41, 1.14-1.75, p-heterogeneity (p-het) = 0.001), BRAF-mutated (mut) (OR = 2.40, 1.41-4.07) compared to BRAF-wild type (wt) (OR = 1.52, 1.24-1.88, p-het = 0.074), KRAS-wt (OR = 1.70, 1.36-2.13) compared to KRAS-mut (OR = 1.26, 0.95-1.68, p-het = 0.039) and CIMP-high (OR = 2.01, 1.40-2.88) compared to CIMP-low/negative CRC (OR = 1.50, 1.22-1.85, p-het=0.101). Current smoking seemed more strongly associated with sessile serrated pathway (CIMP-high + BRAF-mut; OR = 2.39, 1.27-4.52) than with traditional pathway CRC (MSS + CIMP-low/negative + BRAF-wt; OR = 1.50, 1.16-1.94) and no association was observed with alternate pathway CRC (MSS + CIMP-low/negative + KRAS-wt; OR = 1.08, 0.77-1.43). No heterogeneity was observed in alcohol consumption association by molecular subtypes.In this large case-control study, smoking was more strongly associated with MSI-high and KRAS-wt CRC and with cases showing features of the sessile serrated pathway. Association patterns were less clear for alcohol consumption. |
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| 700 | 1 | _ | |a Carr, Prudence R |0 P:(DE-He78)7d7ee36ed0313bbc4c91bc3df5950107 |b 1 |
| 700 | 1 | _ | |a Jansen, Lina |0 P:(DE-He78)bbfe0ebad1e3b608bca2b49d4f86bd09 |b 2 |
| 700 | 1 | _ | |a Roth, Wilfried |b 3 |
| 700 | 1 | _ | |a Alwers, Elizabeth |0 P:(DE-He78)9b2a61b2abe4a64ca23b6783b7c4fe63 |b 4 |
| 700 | 1 | _ | |a Herpel, Esther |b 5 |
| 700 | 1 | _ | |a Kloor, Matthias |0 P:(DE-He78)028ee60cca729028708496826f077b58 |b 6 |
| 700 | 1 | _ | |a Bläker, Hendrik |b 7 |
| 700 | 1 | _ | |a Chang-Claude, Jenny |0 P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253 |b 8 |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 9 |
| 700 | 1 | _ | |a Hoffmeister, Michael |0 P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f |b 10 |e Last author |
| 773 | _ | _ | |a 10.1038/s41416-020-0803-0 |0 PERI:(DE-600)2002452-6 |n 11 |p 1604-1610 |t British journal of cancer |v 122 |y 2020 |x 1532-1827 |
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