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@ARTICLE{Sommerkamp:154285,
      author       = {P. Sommerkamp$^*$ and S. Altamura and S. Renders$^*$ and A.
                      Narr$^*$ and L. Ladel$^*$ and P. Zeisberger$^*$ and P. L.
                      Eiben$^*$ and M. Fawaz and M. A. Rieger$^*$ and N.
                      Cabezas-Wallscheid$^*$ and A. Trumpp$^*$},
      title        = {{D}ifferential {A}lternative {P}olyadenylation {L}andscapes
                      {M}ediate {H}ematopoietic {S}tem {C}ell {A}ctivation and
                      {R}egulate {G}lutamine {M}etabolism.},
      journal      = {Cell stem cell},
      volume       = {26},
      number       = {5},
      issn         = {1934-5909},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2020-00711},
      pages        = {722-738.e7},
      year         = {2020},
      note         = {DKFZ-ZMBH Alliance2020 May
                      7;26(5):722-738.e7#EA:A010#LA:A010#},
      abstract     = {Alternative polyadenylation (APA) is emerging as an
                      important regulatory mechanism of RNA and protein isoform
                      expression by controlling 3' untranslated region (3'-UTR)
                      composition. The relevance of APA in stem cell hierarchies
                      remains elusive. Here, we first demonstrate the requirement
                      of the APA regulator Pabpn1 for hematopoietic stem cell
                      (HSC) function. We then determine the genome-wide APA
                      landscape (APAome) of HSCs and progenitors by performing
                      low-input 3' sequencing paired with bioinformatic pipelines.
                      This reveals transcriptome-wide dynamic APA patterns and an
                      overall shortening of 3'-UTRs during differentiation and
                      upon homeostatic or stress-induced transition from
                      quiescence to proliferation. Specifically, we show that APA
                      regulates activation-induced Glutaminase (Gls) isoform
                      switching by Nudt21. This adaptation of the glutamine
                      metabolism by increasing the GAC:KGA isoform ratio fuels
                      versatile metabolic pathways necessary for HSC self-renewal
                      and proper stress response. Our study establishes APA as a
                      critical regulatory layer orchestrating HSC self-renewal,
                      behavior, and commitment.},
      cin          = {A010 / HD01 / V960},
      ddc          = {570},
      cid          = {I:(DE-He78)A010-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)V960-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32229311},
      doi          = {10.1016/j.stem.2020.03.003},
      url          = {https://inrepo02.dkfz.de/record/154285},
}