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      author       = {A. Babic and N. Sasamoto and B. A. Rosner and S. S.
                      Tworoger and S. J. Jordan and H. A. Risch and H. R. Harris
                      and M. A. Rossing and J. A. Doherty and R. T. Fortner$^*$
                      and J. Chang-Claude$^*$ and M. T. Goodman and P. J. Thompson
                      and K. B. Moysich and R. B. Ness and S. K. Kjaer and A.
                      Jensen and J. M. Schildkraut and L. J. Titus and D. W.
                      Cramer and E. V. Bandera and B. Qin and W. Sieh and V.
                      McGuire and R. Sutphen and C. L. Pearce and A. H. Wu and M.
                      Pike and P. M. Webb and F. Modugno and K. L. Terry},
      title        = {{A}ssociation {B}etween {B}reastfeeding and {O}varian
                      {C}ancer {R}isk.},
      journal      = {JAMA oncology},
      volume       = {6},
      number       = {6},
      issn         = {2374-2437},
      address      = {Chicago, Ill.},
      publisher    = {American Medical Association},
      reportid     = {DKFZ-2020-00724},
      pages        = {e200421},
      year         = {2020},
      abstract     = {Breastfeeding has been associated with a reduced risk of
                      epithelial ovarian cancer in multiple studies, but others
                      showed no association. Whether risk reduction extends beyond
                      that provided by pregnancy alone or differs by histotype is
                      unclear. Furthermore, the observed associations between
                      duration and timing of breastfeeding with ovarian cancer
                      risk have been inconsistent.To determine the association
                      between breastfeeding (ie, ever/never, duration, timing) and
                      ovarian cancer risk overall and by histotype.A pooled
                      analysis of parous women with ovarian cancer and controls
                      from 13 case-control studies participating in the Ovarian
                      Cancer Association Consortium was performed. Odds ratios
                      (ORs) and $95\%$ CIs of the overall association were
                      calculated using multivariable logistic regression and
                      polytomous logistic regression for histotype-specific
                      associations. All data were collected from individual sites
                      from November 1989 to December 2009, and analysis took place
                      from September 2017 to July 2019.Data on breastfeeding
                      history, including duration per child breastfed, age at
                      first and last breastfeeding, and years since last
                      breastfeeding were collected by questionnaire or interview
                      and was harmonized across studies.Diagnosis of epithelial
                      ovarian cancer.A total of 9973 women with ovarian cancer
                      (mean [SD] age, 57.4 [11.1] years) and 13 843 controls
                      (mean [SD] age, 56.4 [11.7] years) were included.
                      Breastfeeding was associated with a $24\%$ lower risk of
                      invasive ovarian cancer (odds ratio [OR], 0.76; $95\%$ CI,
                      0.71-0.80). Independent of parity, ever having breastfed was
                      associated with reduction in risk of all invasive ovarian
                      cancers, particularly high-grade serous and endometrioid
                      cancers. For a single breastfeeding episode, mean
                      breastfeeding duration of 1 to 3 months was associated with
                      $18\%$ lower risk (OR, 0.82; $95\%$ CI, 0.76-0.88), and
                      breastfeeding for 12 or more months was associated with a
                      $34\%$ lower risk (OR, 0.66; $95\%$ CI, 0.58-0.75). More
                      recent breastfeeding was associated with a reduction in risk
                      (OR, 0.56; $95\%$ CI, 0.47-0.66 for <10 years) that
                      persisted for decades (OR, 0.83; $95\%$ CI, 0.77-0.90 for
                      ≥30 years; P for trend = .02).Breastfeeding is
                      associated with a significant decrease in risk of ovarian
                      cancer overall and for the high-grade serous subtype, the
                      most lethal type of ovarian cancer. The findings suggest
                      that breastfeeding is a potentially modifiable factor that
                      may lower risk of ovarian cancer independent of pregnancy
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32239218},
      doi          = {10.1001/jamaoncol.2020.0421},
      url          = {https://inrepo02.dkfz.de/record/154384},