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@ARTICLE{Peter:154387,
      author       = {R. S. Peter and M. L. Meyer and U. Mons$^*$ and B.
                      Schöttker$^*$ and F. Keller and R. Schmucker and W. Koenig
                      and H. Brenner$^*$ and D. Rothenbacher$^*$},
      title        = {{L}ong-term trajectories of anxiety and depression in
                      patients with stable coronary heart disease and risk of
                      subsequent cardiovascular events.},
      journal      = {Depression and anxiety},
      volume       = {37},
      number       = {8},
      issn         = {1091-4269},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley Interscience},
      reportid     = {DKFZ-2020-00727},
      pages        = {784-792},
      year         = {2020},
      note         = {2020 Aug;37(8):784-792#LA:C070#},
      abstract     = {Anxiety and depression seem to be under-recognized in their
                      importance and are often not incorporated in subsequent
                      prevention strategies in routine clinical care of coronary
                      heart disease.The KAROLA cohort included coronary heart
                      disease patients participating in an in-patient
                      rehabilitation program (years 1999/2000) and followed after
                      1, 3, 6, 8, 10, 13, and 15 years. We identified anxiety and
                      depression trajectories based on the hospital anxiety and
                      depression scale subdomains using joint latent class mixture
                      time-to-event models. We included cardiovascular (CV) events
                      and non-CV mortality as competing endpoints.We included
                      1,109 patients $(15.4\%$ female; mean age, 59.4 (standard
                      deviation [SD] = 8.0) years) with baseline covariate
                      data. Over a median follow-up of 14.8 years, participants
                      experienced 324 subsequent CV events. We identified four
                      anxiety and depression trajectory classes, a low-stable
                      class $(52.2\%$ and $69.6\%$ of patients for anxiety and
                      depression, respectively), moderate-stable class $(37.6\%$
                      and $23.8\%),$ increasing class $(2.3\%$ and $3.3\%),$ and
                      high-stable/high-decreasing class $(7.9\%$ and $3.3\%).$ The
                      hazard ratio (HR) for subsequent CV events for the
                      increasing anxiety class was 2.13 $(95\%$ confidence
                      interval [CI], 0.61; 7.45) compared with the low-stable
                      class after covariate adjustment. Patients following the
                      high-decreasing anxiety trajectory showed an HR of 1.72
                      $(95\%$ CI, 1.11; 2.68) and patients following the
                      high-stable depression trajectory an HR of 2.47 $(95\%$ CI,
                      1.35; 4.54).Chronic high anxiety and depression trajectory
                      classes were associated with increased risk of subsequent CV
                      events. Assessments of both symptoms of anxiety and
                      depression during long-term routine medical care are
                      recommended to identify patients who would benefit from
                      appropriate interventions.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
      pid          = {G:(DE-HGF)POF3-323},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32237189},
      doi          = {10.1002/da.23011},
      url          = {https://inrepo02.dkfz.de/record/154387},
}