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@ARTICLE{Gruner:154419,
      author       = {L. Gruner$^*$ and M. Hoffmeister$^*$ and L. Ludwig and H.
                      Brenner$^*$},
      title        = {{E}ffect of {V}arious {I}nvitation {S}chemes on the {U}se
                      of {F}ecal {I}mmunochemical {T}ests for {C}olorectal
                      {C}ancer {S}creening: {P}rotocol for a {R}andomized
                      {C}ontrolled {T}rial.},
      journal      = {Journal of medical internet research / Research Protocols
                      Research Protocols [...]},
      volume       = {9},
      number       = {4},
      issn         = {1929-0748},
      address      = {Toronto},
      reportid     = {DKFZ-2020-00750},
      pages        = {e16413},
      year         = {2020},
      note         = {#EA:C070#LA:C070#},
      abstract     = {Fecal occult blood testing has been offered for many years
                      in the German health care system, but participation rates
                      have been notoriously low.The aim of this study is to
                      evaluate the effect of various personal invitation schemes
                      on the use of fecal immunochemical tests (FITs) in persons
                      aged 50-54 years.This study consists of a three-armed
                      randomized controlled trial: (1) arm A: an invitation letter
                      from a health insurance plan including a FIT test kit, (2)
                      arm B: an invitation letter from a health insurance plan
                      including an offer to receive a free FIT test kit by mail
                      upon easy-to-handle request (ie, by internet, fax, or reply
                      mail), and (3) arm C: an information letter on an existing
                      colonoscopy offer (ie, control). Within arms A and B, a
                      random selection of $50\%$ of the study population will
                      receive reminder letters, the effects of which are to be
                      evaluated in a substudy.A total of 17,532 persons aged 50-54
                      years in a statutory health insurance plan in the southwest
                      of Germany-AOK Baden-Wuerttemberg-were sent an initial
                      invitation, and 5825 reminder letters were sent out. The
                      primary end point is FIT usage within 1 year from receipt of
                      invitation or information letter. The main secondary end
                      points include gender-specific FIT usage within 1 year,
                      rates of positive test results, rates of colonoscopies
                      following a positive test result, and detection rates of
                      advanced neoplasms. The study was launched in September
                      2017. Data collection and workup were completed in fall
                      2019.This randomized controlled trial will provide important
                      empirical evidence for enhancing colorectal cancer screening
                      offers in the German health care system.German Clinical
                      Trials Register (DRKS) DRKS00011858;
                      https://bit.ly/2UBTIdt.DERR1-10.2196/16413.},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32242518},
      doi          = {10.2196/16413},
      url          = {https://inrepo02.dkfz.de/record/154419},
}