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000154427 0247_ $$2doi$$a10.1053/j.gastro.2020.03.063
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000154427 1001_ $$0P:(DE-He78)834e8bc4d74592e3b999100c157215f5$$aTian, Yu$$b0$$eFirst author$$udkfz
000154427 245__ $$aCalculating Starting Age for Screening in Relatives of Patients With Colorectal Cancer Based on Data From Large Nationwide Datasets.
000154427 260__ $$aPhiladelphia, Pa. [u.a.]$$bSaunders$$c2020
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000154427 500__ $$aVolume 159, Issue 1, July 2020, Pages 159-168.e3#EA:C120#LA:C120#
000154427 520__ $$aAlthough colorectal cancer (CRC) screening guidelines acknowledge the need for earlier screening for high-risk individuals, such as those with family history of CRC, there is limited information on how many years earlier these high-risk individuals should be screened; current practice is based on weak evidence. We aimed to provide risk-adapted recommendations on starting age of CRC screening for individuals with different family histories.We collected data from nationwide family-cancer datasets in Sweden and calculated risk-adapted starting ages of screening for individuals with different family histories of CRC. Family history was defined as a dynamic (time-dependent) variable allowing for changes during the follow-up period of 1958 through 2015.During a follow up of 12,829,251 individuals with genealogy information, 173,796 developed CRC. The 10-year cumulative risk for the average-risk population at age 50 y (guideline-recommended age for screening) was 0.44%. Individuals with different family histories of CRC attained this equivalent 0.44% risk 3-32 y earlier than their peers in the general population without such a family history. For example, individuals with 1 affected first-degree relative diagnosed before age 45 reached the corresponding risk level 16 y earlier.We determined risk-adapted starting ages of CRC screening for close or distant relatives of patients with CRC, using high-quality nationwide datasets. These findings might be used in counselling individuals about the appropriate age to start CRC screening, to optimize screening practice, and to supplement guidelines for CRC screening.
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000154427 7001_ $$0P:(DE-He78)e56510c7dedbff7a279ad76dad80eeda$$aKharazmi, Elham$$b1$$udkfz
000154427 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b2$$udkfz
000154427 7001_ $$0P:(DE-He78)62b0f1b5eccef2b5f2e55b7f13ccde6d$$aXu, Xing$$b3$$udkfz
000154427 7001_ $$aSundquist, Kristina$$b4
000154427 7001_ $$aSundquist, Jan$$b5
000154427 7001_ $$0P:(DE-He78)b510b884502b619724039bf33fdae68a$$aFallah, Mahdi$$b6$$eLast author$$udkfz
000154427 773__ $$0PERI:(DE-600)1478699-0$$a10.1053/j.gastro.2020.03.063$$gp. S0016508520304467$$n1$$p159-168.e3$$tGastroenterology$$v159$$x0016-5085$$y2020
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