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@ARTICLE{Tian:154427,
      author       = {Y. Tian$^*$ and E. Kharazmi$^*$ and H. Brenner$^*$ and X.
                      Xu$^*$ and K. Sundquist and J. Sundquist and M. Fallah$^*$},
      title        = {{C}alculating {S}tarting {A}ge for {S}creening in
                      {R}elatives of {P}atients {W}ith {C}olorectal {C}ancer
                      {B}ased on {D}ata {F}rom {L}arge {N}ationwide {D}atasets.},
      journal      = {Gastroenterology},
      volume       = {159},
      number       = {1},
      issn         = {0016-5085},
      address      = {Philadelphia, Pa. [u.a.]},
      publisher    = {Saunders},
      reportid     = {DKFZ-2020-00755},
      pages        = {159-168.e3},
      year         = {2020},
      note         = {Volume 159, Issue 1, July 2020, Pages
                      159-168.e3#EA:C120#LA:C120#},
      abstract     = {Although colorectal cancer (CRC) screening guidelines
                      acknowledge the need for earlier screening for high-risk
                      individuals, such as those with family history of CRC, there
                      is limited information on how many years earlier these
                      high-risk individuals should be screened; current practice
                      is based on weak evidence. We aimed to provide risk-adapted
                      recommendations on starting age of CRC screening for
                      individuals with different family histories.We collected
                      data from nationwide family-cancer datasets in Sweden and
                      calculated risk-adapted starting ages of screening for
                      individuals with different family histories of CRC. Family
                      history was defined as a dynamic (time-dependent) variable
                      allowing for changes during the follow-up period of 1958
                      through 2015.During a follow up of 12,829,251 individuals
                      with genealogy information, 173,796 developed CRC. The
                      10-year cumulative risk for the average-risk population at
                      age 50 y (guideline-recommended age for screening) was
                      $0.44\%.$ Individuals with different family histories of CRC
                      attained this equivalent $0.44\%$ risk 3-32 y earlier than
                      their peers in the general population without such a family
                      history. For example, individuals with 1 affected
                      first-degree relative diagnosed before age 45 reached the
                      corresponding risk level 16 y earlier.We determined
                      risk-adapted starting ages of CRC screening for close or
                      distant relatives of patients with CRC, using high-quality
                      nationwide datasets. These findings might be used in
                      counselling individuals about the appropriate age to start
                      CRC screening, to optimize screening practice, and to
                      supplement guidelines for CRC screening.},
      cin          = {C120 / C070 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32251666},
      doi          = {10.1053/j.gastro.2020.03.063},
      url          = {https://inrepo02.dkfz.de/record/154427},
}