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| 024 | 7 | _ | |a 10.1053/j.gastro.2020.03.063 |2 doi |
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| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Tian, Yu |0 P:(DE-He78)834e8bc4d74592e3b999100c157215f5 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Calculating Starting Age for Screening in Relatives of Patients With Colorectal Cancer Based on Data From Large Nationwide Datasets. |
| 260 | _ | _ | |a Philadelphia, Pa. [u.a.] |c 2020 |b Saunders |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1600867761_6352 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a Volume 159, Issue 1, July 2020, Pages 159-168.e3#EA:C120#LA:C120# |
| 520 | _ | _ | |a Although colorectal cancer (CRC) screening guidelines acknowledge the need for earlier screening for high-risk individuals, such as those with family history of CRC, there is limited information on how many years earlier these high-risk individuals should be screened; current practice is based on weak evidence. We aimed to provide risk-adapted recommendations on starting age of CRC screening for individuals with different family histories.We collected data from nationwide family-cancer datasets in Sweden and calculated risk-adapted starting ages of screening for individuals with different family histories of CRC. Family history was defined as a dynamic (time-dependent) variable allowing for changes during the follow-up period of 1958 through 2015.During a follow up of 12,829,251 individuals with genealogy information, 173,796 developed CRC. The 10-year cumulative risk for the average-risk population at age 50 y (guideline-recommended age for screening) was 0.44%. Individuals with different family histories of CRC attained this equivalent 0.44% risk 3-32 y earlier than their peers in the general population without such a family history. For example, individuals with 1 affected first-degree relative diagnosed before age 45 reached the corresponding risk level 16 y earlier.We determined risk-adapted starting ages of CRC screening for close or distant relatives of patients with CRC, using high-quality nationwide datasets. These findings might be used in counselling individuals about the appropriate age to start CRC screening, to optimize screening practice, and to supplement guidelines for CRC screening. |
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| 700 | 1 | _ | |a Sundquist, Kristina |b 4 |
| 700 | 1 | _ | |a Sundquist, Jan |b 5 |
| 700 | 1 | _ | |a Fallah, Mahdi |0 P:(DE-He78)b510b884502b619724039bf33fdae68a |b 6 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1053/j.gastro.2020.03.063 |g p. S0016508520304467 |0 PERI:(DE-600)1478699-0 |n 1 |p 159-168.e3 |t Gastroenterology |v 159 |y 2020 |x 0016-5085 |
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