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000154433 1001_ $$0P:(DE-He78)ab9d733d2007eee41c85bf65426a687d$$aEyl, Ruth Elisa$$b0$$eFirst author
000154433 245__ $$aPhysical activity and long-term quality of life among colorectal cancer survivors - a population-based prospective study.
000154433 260__ $$aPhiladelphia, Pa.$$bAACR$$c2020
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000154433 520__ $$aEvidence suggests that physical activity(PA) is positively associated with health-related quality of life(QOL) in colorectal cancer(CRC) survivors. However, little is known regarding long-term effects of PA on QOL and if pre-diagnosis PA is associated with QOL in the years after diagnosis. Our study aimed to investigate the association of pre- and post-diagnosis PA with long-term QOL in CRC survivors. This study is based on a population-based cohort from Germany of 1781 newly diagnosed CRC survivors over a five-year period. Physical activity was assessed at diagnosis and at five-year follow up(5YFU). Quality of life was assessed by the EORTC Quality of Life Questionnaire-Core 30 at 5YFU. Multivariable linear regression was used to explore associations between pre- and post-diagnosis PA and QOL. No evidence of a positive association between higher levels of pre-diagnosis PA and better long-term QOL was found. Higher levels of pre-diagnosis work-related PA and vigorous PA were even associated with decreased QOL in domains such as cognitive (Beta(ß)= -2.52, 95% confidence interval(CI)=-3.77,-1.27; ß=-1.92, CI=-3.17,-0.67) and emotional functioning (ß=-2.52, CI=-3.84,-1.19; ß=-2.12, CI=-3.44,-0.80). In cross-sectional analyses, higher post-diagnosis PA was strongly associated with higher QOL. Survivors physically active at both pre- and post-diagnosis as well as survivors who increased their PA between pre- and post-diagnosis reported significantly higher long-term QOL compared to survivors who remained inactive at pre- and post-diagnosis. In this study, higher pre-diagnosis PA does not appear to be associated with higher QOL among long-term CRC survivors but our results support the importance of ongoing PA throughout survivorship.
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000154433 7001_ $$0P:(DE-He78)13aa5fe9d9961c9fd67193befb0dcf88$$aKoch-Gallenkamp, Lena$$b1
000154433 7001_ $$0P:(DE-He78)bbfe0ebad1e3b608bca2b49d4f86bd09$$aJansen, Lina$$b2
000154433 7001_ $$0P:(DE-He78)6c2a1ea8cce3580fe2d1c1df120a92b9$$aWalter, Viola$$b3
000154433 7001_ $$0P:(DE-He78)7d7ee36ed0313bbc4c91bc3df5950107$$aCarr, Prudence R$$b4
000154433 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b5
000154433 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b6
000154433 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b7
000154433 7001_ $$0P:(DE-He78)d023fdf423d87ee6c710e34dd7581fa0$$aArndt, Volker$$b8$$eLast author
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