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@ARTICLE{Eyl:154433,
      author       = {R. E. Eyl$^*$ and L. Koch-Gallenkamp$^*$ and L. Jansen$^*$
                      and V. Walter$^*$ and P. R. Carr$^*$ and M. Hoffmeister$^*$
                      and J. Chang-Claude$^*$ and H. Brenner$^*$ and V. Arndt$^*$},
      title        = {{P}hysical activity and long-term quality of life among
                      colorectal cancer survivors - a population-based prospective
                      study.},
      journal      = {Cancer Prevention Research},
      volume       = {13},
      number       = {7},
      issn         = {1940-6215},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2020-00761},
      pages        = {611-622},
      year         = {2020},
      note         = {2020 Jul;13(7):611-622#EA:C070#LA:C071#},
      abstract     = {Evidence suggests that physical activity(PA) is positively
                      associated with health-related quality of life(QOL) in
                      colorectal cancer(CRC) survivors. However, little is known
                      regarding long-term effects of PA on QOL and if
                      pre-diagnosis PA is associated with QOL in the years after
                      diagnosis. Our study aimed to investigate the association of
                      pre- and post-diagnosis PA with long-term QOL in CRC
                      survivors. This study is based on a population-based cohort
                      from Germany of 1781 newly diagnosed CRC survivors over a
                      five-year period. Physical activity was assessed at
                      diagnosis and at five-year follow up(5YFU). Quality of life
                      was assessed by the EORTC Quality of Life Questionnaire-Core
                      30 at 5YFU. Multivariable linear regression was used to
                      explore associations between pre- and post-diagnosis PA and
                      QOL. No evidence of a positive association between higher
                      levels of pre-diagnosis PA and better long-term QOL was
                      found. Higher levels of pre-diagnosis work-related PA and
                      vigorous PA were even associated with decreased QOL in
                      domains such as cognitive (Beta(ß)= -2.52, $95\%$
                      confidence interval(CI)=-3.77,-1.27; ß=-1.92,
                      CI=-3.17,-0.67) and emotional functioning (ß=-2.52,
                      CI=-3.84,-1.19; ß=-2.12, CI=-3.44,-0.80). In
                      cross-sectional analyses, higher post-diagnosis PA was
                      strongly associated with higher QOL. Survivors physically
                      active at both pre- and post-diagnosis as well as survivors
                      who increased their PA between pre- and post-diagnosis
                      reported significantly higher long-term QOL compared to
                      survivors who remained inactive at pre- and post-diagnosis.
                      In this study, higher pre-diagnosis PA does not appear to be
                      associated with higher QOL among long-term CRC survivors but
                      our results support the importance of ongoing PA throughout
                      survivorship.},
      cin          = {C070 / C120 / HD01 / C020 / C071},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)C020-20160331 /
                      I:(DE-He78)C071-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32253267},
      doi          = {10.1158/1940-6207.CAPR-19-0377},
      url          = {https://inrepo02.dkfz.de/record/154433},
}