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| 001 | 154433 | ||
| 005 | 20240229123101.0 | ||
| 024 | 7 | _ | |a 10.1158/1940-6207.CAPR-19-0377 |2 doi |
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| 037 | _ | _ | |a DKFZ-2020-00761 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Eyl, Ruth Elisa |0 P:(DE-He78)ab9d733d2007eee41c85bf65426a687d |b 0 |e First author |
| 245 | _ | _ | |a Physical activity and long-term quality of life among colorectal cancer survivors - a population-based prospective study. |
| 260 | _ | _ | |a Philadelphia, Pa. |c 2020 |b AACR |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 500 | _ | _ | |a 2020 Jul;13(7):611-622#EA:C070#LA:C071# |
| 520 | _ | _ | |a Evidence suggests that physical activity(PA) is positively associated with health-related quality of life(QOL) in colorectal cancer(CRC) survivors. However, little is known regarding long-term effects of PA on QOL and if pre-diagnosis PA is associated with QOL in the years after diagnosis. Our study aimed to investigate the association of pre- and post-diagnosis PA with long-term QOL in CRC survivors. This study is based on a population-based cohort from Germany of 1781 newly diagnosed CRC survivors over a five-year period. Physical activity was assessed at diagnosis and at five-year follow up(5YFU). Quality of life was assessed by the EORTC Quality of Life Questionnaire-Core 30 at 5YFU. Multivariable linear regression was used to explore associations between pre- and post-diagnosis PA and QOL. No evidence of a positive association between higher levels of pre-diagnosis PA and better long-term QOL was found. Higher levels of pre-diagnosis work-related PA and vigorous PA were even associated with decreased QOL in domains such as cognitive (Beta(ß)= -2.52, 95% confidence interval(CI)=-3.77,-1.27; ß=-1.92, CI=-3.17,-0.67) and emotional functioning (ß=-2.52, CI=-3.84,-1.19; ß=-2.12, CI=-3.44,-0.80). In cross-sectional analyses, higher post-diagnosis PA was strongly associated with higher QOL. Survivors physically active at both pre- and post-diagnosis as well as survivors who increased their PA between pre- and post-diagnosis reported significantly higher long-term QOL compared to survivors who remained inactive at pre- and post-diagnosis. In this study, higher pre-diagnosis PA does not appear to be associated with higher QOL among long-term CRC survivors but our results support the importance of ongoing PA throughout survivorship. |
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| 700 | 1 | _ | |a Koch-Gallenkamp, Lena |0 P:(DE-He78)13aa5fe9d9961c9fd67193befb0dcf88 |b 1 |
| 700 | 1 | _ | |a Jansen, Lina |0 P:(DE-He78)bbfe0ebad1e3b608bca2b49d4f86bd09 |b 2 |
| 700 | 1 | _ | |a Walter, Viola |0 P:(DE-He78)6c2a1ea8cce3580fe2d1c1df120a92b9 |b 3 |
| 700 | 1 | _ | |a Carr, Prudence R |0 P:(DE-He78)7d7ee36ed0313bbc4c91bc3df5950107 |b 4 |
| 700 | 1 | _ | |a Hoffmeister, Michael |0 P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f |b 5 |
| 700 | 1 | _ | |a Chang-Claude, Jenny |0 P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253 |b 6 |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 7 |
| 700 | 1 | _ | |a Arndt, Volker |0 P:(DE-He78)d023fdf423d87ee6c710e34dd7581fa0 |b 8 |e Last author |
| 773 | _ | _ | |a 10.1158/1940-6207.CAPR-19-0377 |g p. canprevres.0377.2019 - |0 PERI:(DE-600)2422346-3 |n 7 |p 611-622 |t Cancer Prevention Research |v 13 |y 2020 |x 1940-6215 |
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