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@ARTICLE{VishramNielsen:154464,
      author       = {J. K. K. Vishram-Nielsen and S. Laurent and P. M. Nilsson
                      and A. Linneberg and T. S. G. Sehested and S. V. Greve and
                      M. Pareek and L. Palmieri and S. Giampaoli and C.
                      Donfrancesco and F. Kee and G. Mancia and G. Cesana and G.
                      Veronesi and K. Kuulasmaa and V. Salomaa and J. Kontto and
                      T. Palosaari and S. Sans and J. Ferrieres and J.
                      Dallongeville and S. Söderberg and M. Moitry and W. Drygas
                      and A. Tamosiunas$^*$ and A. Peters$^*$ and H. Brenner$^*$
                      and I. Njolstad and M. H. Olsen},
      collaboration = {M. Project},
      title        = {{D}oes {E}stimated {P}ulse {W}ave {V}elocity {A}dd
                      {P}rognostic {I}nformation?: {MORGAM} {P}rospective {C}ohort
                      {P}roject.},
      journal      = {Hypertension},
      volume       = {75},
      number       = {6},
      issn         = {1524-4563},
      address      = {Baltimore, Md.},
      publisher    = {Williams $\&$ Wilkins},
      reportid     = {DKFZ-2020-00786},
      pages        = {1420-1428},
      year         = {2020},
      note         = {2020 Jun;75(6):1420-1428},
      abstract     = {The Reference Values for Arterial Stiffness Collaboration
                      has derived an equation using age and mean blood pressure to
                      estimated pulse wave velocity (ePWV), which predicted
                      cardiovascular events independently of Systematic COoronary
                      Risk Evaluation (SCORE) and Framingham Risk Score. The study
                      aim was to investigate the independent association between
                      ePWV and clinical outcomes in 107 599 apparently healthy
                      subjects $(53\%$ men) aged 19 to 97 years from the MORGAM
                      Project who were included between 1982 and 2002 in 38
                      cohorts from 11 countries. Using multiple Cox-regression
                      analyses, the predictive value of ePWV was calculated
                      adjusting for country of inclusion and either SCORE,
                      Framingham Risk Score, or traditional cardiovascular risk
                      factors (age, sex, smoking, systolic blood pressure, body
                      mass index [BMI], total and high-density lipoprotein
                      cholesterol). Cardiovascular mortality consisted of fatal
                      stroke, fatal myocardial infarction, or coronary death, and
                      the composite cardiovascular end point consisted of stroke,
                      myocardial infarction, or coronary death. Model
                      discrimination was assessed using Harrell's C-statistic.
                      Adjusting for country and logSCORE or Framingham Risk Score,
                      ePWV was associated with all-cause mortality (hazard ratio,
                      1.23 $[95\%$ CI 1.20-1.25] per m/s or 1.32 [1.29-1.34]),
                      cardiovascular mortality (1.26 [1.21-1.32] or 1.35
                      [1.31-1.40]), and composite cardiovascular end point (1.19
                      [1.16-1.22] or 1.23 [1.20-1.25]; all P<0.001). However,
                      after adjusting for traditional cardiovascular risk factors,
                      ePWV was only associated with all-cause mortality (1.15
                      [1.08-1.22], P<0.001) and not with cardiovascular mortality
                      (0.97 [0.91-1.03]) nor composite cardiovascular end point
                      (1.10 [0.97-1.26]). The areas under the last 3 receiver
                      operator characteristic curves remained unchanged when
                      adding ePWV. Elevated ePWV was associated with subsequent
                      mortality and cardiovascular morbidity independently of
                      systematic coronary risk evaluation and Framingham Risk
                      Score but not independently of traditional cardiovascular
                      risk factors.},
      cin          = {C070 / C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32275189},
      doi          = {10.1161/HYPERTENSIONAHA.119.14088},
      url          = {https://inrepo02.dkfz.de/record/154464},
}