%0 Journal Article
%A Chen, Hongda
%A Lu, Ming
%A Liu, Chengcheng
%A Zou, Shuangmei
%A Du, Lingbin
%A Liao, Xianzhen
%A Dong, Dong
%A Wei, Donghua
%A Gao, Yi
%A Zhu, Chen
%A Zhu, Liming
%A Zheng, Weifang
%A Xiao, Haifan
%A Kong, Yunxin
%A Yin, Huiping
%A Zhou, Hai
%A Ying, Rongbiao
%A Wang, Baoquan
%A Zhang, Juan
%A Zhang, Xiaopeng
%A Zhang, Qiang
%A Zhang, Xuan
%A Zhang, Yuhan
%A Wang, Hong
%A Guo, Lanwei
%A Liu, Li
%A Ren, Jiansong
%A Shi, Jufang
%A Li, Ni
%A Miao, Xiaoping
%A Brenner, Hermann
%A Dai, Min
%T Comparative Evaluation of Participation and Diagnostic Yield of Colonoscopy vs Fecal Immunochemical Test vs Risk-Adapted Screening in Colorectal Cancer Screening: Interim Analysis of a Multicenter Randomized Controlled Trial (TARGET-C).
%J The American journal of gastroenterology
%V 115
%N 8
%@ 0002-9270
%C Alphen aan den Rijn, The Netherlands
%I Wolters Kluwer Health, Inc.
%M DKFZ-2020-00787
%P 1264-1274
%D 2020
%Z Volume 115, Issue 8, 1 August 2020, Pages 1264-1274
%X In colorectal cancer screening, implementing risk-adapted screening might be more effective than traditional screening strategies. We aimed to compare the effectiveness of a risk-adapted screening strategy with colonoscopy and fecal immunochemical test (FIT) in colorectal cancer screening.A randomized controlled trial was conducted in 6 centers in China since May 2018. Nineteen thousand five hundred forty-six eligible participants aged 50-74 years were recruited and randomly allocated into 1 of the 3 screening groups in a 1:2:2 ratio: (i) one-time colonoscopy (n = 3,916), (ii) annual FIT (n = 7,854), and (iii) annual risk-adapted screening (n = 7,776). Based on the risk-stratification score, high-risk subjects were referred for colonoscopy and low-risk ones were referred for FIT. All subjects with positive FIT were referred for diagnostic colonoscopy. The detection rate of advanced neoplasm was the primary outcome. The study is registered with the China Clinical Trial Registry (www.chictr.org.cn Identifier: ChiCTR1800015506).For baseline screening, the participation rates of the colonoscopy, FIT, and risk-adapted screening groups were 42.5
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32282342
%R 10.14309/ajg.0000000000000624
%U https://inrepo02.dkfz.de/record/154465