TY  - JOUR
AU  - Chen, Hongda
AU  - Lu, Ming
AU  - Liu, Chengcheng
AU  - Zou, Shuangmei
AU  - Du, Lingbin
AU  - Liao, Xianzhen
AU  - Dong, Dong
AU  - Wei, Donghua
AU  - Gao, Yi
AU  - Zhu, Chen
AU  - Zhu, Liming
AU  - Zheng, Weifang
AU  - Xiao, Haifan
AU  - Kong, Yunxin
AU  - Yin, Huiping
AU  - Zhou, Hai
AU  - Ying, Rongbiao
AU  - Wang, Baoquan
AU  - Zhang, Juan
AU  - Zhang, Xiaopeng
AU  - Zhang, Qiang
AU  - Zhang, Xuan
AU  - Zhang, Yuhan
AU  - Wang, Hong
AU  - Guo, Lanwei
AU  - Liu, Li
AU  - Ren, Jiansong
AU  - Shi, Jufang
AU  - Li, Ni
AU  - Miao, Xiaoping
AU  - Brenner, Hermann
AU  - Dai, Min
TI  - Comparative Evaluation of Participation and Diagnostic Yield of Colonoscopy vs Fecal Immunochemical Test vs Risk-Adapted Screening in Colorectal Cancer Screening: Interim Analysis of a Multicenter Randomized Controlled Trial (TARGET-C).
JO  - The American journal of gastroenterology
VL  - 115
IS  - 8
SN  - 0002-9270
CY  - Alphen aan den Rijn, The Netherlands
PB  - Wolters Kluwer Health, Inc.
M1  - DKFZ-2020-00787
SP  - 1264-1274
PY  - 2020
N1  - Volume 115, Issue 8, 1 August 2020, Pages 1264-1274
AB  - In colorectal cancer screening, implementing risk-adapted screening might be more effective than traditional screening strategies. We aimed to compare the effectiveness of a risk-adapted screening strategy with colonoscopy and fecal immunochemical test (FIT) in colorectal cancer screening.A randomized controlled trial was conducted in 6 centers in China since May 2018. Nineteen thousand five hundred forty-six eligible participants aged 50-74 years were recruited and randomly allocated into 1 of the 3 screening groups in a 1:2:2 ratio: (i) one-time colonoscopy (n = 3,916), (ii) annual FIT (n = 7,854), and (iii) annual risk-adapted screening (n = 7,776). Based on the risk-stratification score, high-risk subjects were referred for colonoscopy and low-risk ones were referred for FIT. All subjects with positive FIT were referred for diagnostic colonoscopy. The detection rate of advanced neoplasm was the primary outcome. The study is registered with the China Clinical Trial Registry (www.chictr.org.cn Identifier: ChiCTR1800015506).For baseline screening, the participation rates of the colonoscopy, FIT, and risk-adapted screening groups were 42.5
LB  - PUB:(DE-HGF)16
C6  - pmid:32282342
DO  - DOI:10.14309/ajg.0000000000000624
UR  - https://inrepo02.dkfz.de/record/154465
ER  -