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000154467 0247_ $$2doi$$a10.1002/alz.12081
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000154467 1001_ $$0P:(DE-He78)b09508a4c4afe85c57dd131eefa689ea$$aTrares, Kira$$b0$$eFirst author$$udkfz
000154467 245__ $$aAssociations of urinary 8-iso-prostaglandin F2α levels with all-cause dementia, Alzheimer's disease, and vascular dementia incidence: results from a prospective cohort study.
000154467 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2020
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000154467 520__ $$aProspective studies on a potential association of 8-iso-prostaglandin F2α (8-iso-PGF2α ) levels, a biomarker of lipid peroxidation, with dementia are limited.Multivariate Cox regression models were used to assess potential associations of urinary 8-iso-PGF2α levels with all-cause, Alzheimer's disease (AD), and vascular dementia (VD) incidence in 5853 older adults from a German, population-based cohort.Over 14 years of follow-up, 365 all-cause dementia cases including 127 VD and 109 AD cases were diagnosed. Participants in the top compared to the bottom 8-iso-PGF2α tertile had a 45% increased risk of all-cause dementia incidence (hazard ratio [95% confidence interval]: 1.45 [1.12 to 1.88]). Interaction with the apolipoprotein E (APOE) ԑ4/ԑ4 genotype was detected (P = .02). Furthermore, continuously modeled, logarithmized 8-iso-PGF2α levels were statistically significantly associated with all-cause dementia and AD incidence.Oxidative stress may be involved in the pathogenesis of dementia. Individuals with increased 8-iso-PGF2α levels and the APOE ԑ4/ԑ4 genotype showed a considerably increased dementia risk.
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000154467 7001_ $$0P:(DE-He78)8218df9f6f41792399cd3a29b587e4e7$$aGào, Xīn$$b1$$udkfz
000154467 7001_ $$aPerna, Laura$$b2
000154467 7001_ $$aRujescu, Dan$$b3
000154467 7001_ $$0P:(DE-HGF)0$$aStocker, Hannah$$b4
000154467 7001_ $$0P:(DE-He78)6cc3cc35505b446fde081e7cd89a4b87$$aMöllers, Tobias$$b5$$udkfz
000154467 7001_ $$aBeyreuther, Konrad$$b6
000154467 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b7$$udkfz
000154467 7001_ $$0P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aSchöttker, Ben$$b8$$eLast author$$udkfz
000154467 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.12081$$n5$$p804-813$$tAlzheimer's and dementia$$v16$$x1552-5260$$y2020
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