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@ARTICLE{Trares:154467,
      author       = {K. Trares$^*$ and X. Gào$^*$ and L. Perna and D. Rujescu
                      and H. Stocker$^*$ and T. Möllers$^*$ and K. Beyreuther and
                      H. Brenner$^*$ and B. Schöttker$^*$},
      title        = {{A}ssociations of urinary 8-iso-prostaglandin {F}2α levels
                      with all-cause dementia, {A}lzheimer's disease, and vascular
                      dementia incidence: results from a prospective cohort
                      study.},
      journal      = {Alzheimer's and dementia},
      volume       = {16},
      number       = {5},
      issn         = {1552-5260},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2020-00789},
      pages        = {804-813},
      year         = {2020},
      note         = {2020 May;16(5):804-813#EA:C070#LA:C070#},
      abstract     = {Prospective studies on a potential association of
                      8-iso-prostaglandin F2α (8-iso-PGF2α ) levels, a biomarker
                      of lipid peroxidation, with dementia are
                      limited.Multivariate Cox regression models were used to
                      assess potential associations of urinary 8-iso-PGF2α levels
                      with all-cause, Alzheimer's disease (AD), and vascular
                      dementia (VD) incidence in 5853 older adults from a German,
                      population-based cohort.Over 14 years of follow-up, 365
                      all-cause dementia cases including 127 VD and 109 AD cases
                      were diagnosed. Participants in the top compared to the
                      bottom 8-iso-PGF2α tertile had a $45\%$ increased risk of
                      all-cause dementia incidence (hazard ratio $[95\%$
                      confidence interval]: 1.45 [1.12 to 1.88]). Interaction with
                      the apolipoprotein E (APOE) ԑ4/ԑ4 genotype was detected (P
                      = .02). Furthermore, continuously modeled, logarithmized
                      8-iso-PGF2α levels were statistically significantly
                      associated with all-cause dementia and AD
                      incidence.Oxidative stress may be involved in the
                      pathogenesis of dementia. Individuals with increased
                      8-iso-PGF2α levels and the APOE ԑ4/ԑ4 genotype showed a
                      considerably increased dementia risk.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32281305},
      doi          = {10.1002/alz.12081},
      url          = {https://inrepo02.dkfz.de/record/154467},
}