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| 100 | 1 | _ | |a Trares, Kira |0 P:(DE-He78)b09508a4c4afe85c57dd131eefa689ea |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Associations of urinary 8-iso-prostaglandin F2α levels with all-cause dementia, Alzheimer's disease, and vascular dementia incidence: results from a prospective cohort study. |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2020 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 500 | _ | _ | |a 2020 May;16(5):804-813#EA:C070#LA:C070# |
| 520 | _ | _ | |a Prospective studies on a potential association of 8-iso-prostaglandin F2α (8-iso-PGF2α ) levels, a biomarker of lipid peroxidation, with dementia are limited.Multivariate Cox regression models were used to assess potential associations of urinary 8-iso-PGF2α levels with all-cause, Alzheimer's disease (AD), and vascular dementia (VD) incidence in 5853 older adults from a German, population-based cohort.Over 14 years of follow-up, 365 all-cause dementia cases including 127 VD and 109 AD cases were diagnosed. Participants in the top compared to the bottom 8-iso-PGF2α tertile had a 45% increased risk of all-cause dementia incidence (hazard ratio [95% confidence interval]: 1.45 [1.12 to 1.88]). Interaction with the apolipoprotein E (APOE) ԑ4/ԑ4 genotype was detected (P = .02). Furthermore, continuously modeled, logarithmized 8-iso-PGF2α levels were statistically significantly associated with all-cause dementia and AD incidence.Oxidative stress may be involved in the pathogenesis of dementia. Individuals with increased 8-iso-PGF2α levels and the APOE ԑ4/ԑ4 genotype showed a considerably increased dementia risk. |
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| 700 | 1 | _ | |a Gào, Xīn |0 P:(DE-He78)8218df9f6f41792399cd3a29b587e4e7 |b 1 |u dkfz |
| 700 | 1 | _ | |a Perna, Laura |b 2 |
| 700 | 1 | _ | |a Rujescu, Dan |b 3 |
| 700 | 1 | _ | |a Stocker, Hannah |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Möllers, Tobias |0 P:(DE-He78)6cc3cc35505b446fde081e7cd89a4b87 |b 5 |u dkfz |
| 700 | 1 | _ | |a Beyreuther, Konrad |b 6 |
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| 700 | 1 | _ | |a Schöttker, Ben |0 P:(DE-He78)c67a12496b8aac150c0eef888d808d46 |b 8 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1002/alz.12081 |0 PERI:(DE-600)2201940-6 |n 5 |p 804-813 |t Alzheimer's and dementia |v 16 |y 2020 |x 1552-5260 |
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