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| 001 | 154601 | ||
| 005 | 20240229133504.0 | ||
| 024 | 7 | _ | |a 10.1093/jnci/djaa058 |2 doi |
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| 100 | 1 | _ | |a Campbell, Peter T |b 0 |
| 245 | _ | _ | |a Association of body mass index with colorectal cancer risk by genome-wide variants. |
| 260 | _ | _ | |a Oxford |c 2021 |b Oxford Univ. Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1611562385_14751 |2 PUB:(DE-HGF) |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2021 Jan 4;113(1):38-47 |
| 520 | _ | _ | |a Body mass index (BMI) is a complex phenotype that may interact with genetic variants to influence colorectal cancer risk.We tested multiplicative statistical interactions between BMI (per 5 kg·m2) and approximately 2.7 million single nucleotide polymorphisms (SNPs) with colorectal cancer risk among 14,059 colorectal cancer case (53.2% women) and 14,416 control (53.8% women) participants. All analyses were stratified by sex a priori. Statistical methods included two-step (i.e., Cocktail method) and single-step (i.e., case-control logistic regression and a joint 2-degree of freedom test) procedures. All statistical tests were two-sided.Each 5 kg·m2 increase in BMI was associated with higher risks of colorectal cancer, less so for women (odds ratio [OR]: 1.14; 95% confidence intervals [CI]: 1.11-1.18; p-value: 9.75 x 10-17) than for men (OR: 1.26; 95% CI: 1.20-1.32; p-value: 2.13 x 10-24). The two-step Cocktail method identified an interaction for women, but not men, between BMI and a SMAD7 intronic variant at 18q21.1 (rs4939827; p-observed: 0.0009; p-threshold: 0.005). A joint 2-degree of freedom test was consistent with this finding for women (joint p-value: 2.43 x 10-10). Each 5 kg·m2 increase in BMI was more strongly associated with colorectal cancer risk for women with the rs4939827-CC genotype (OR: 1.24; 95% CI: 1.16-1.32; p-value: 2.60 x 10-10) than for women with the CT (OR: 1.14; 95% CI: 1.09-1.19; p-value: 1.04 x 10-8) or TT (OR: 1.07; 95% CI: 1.01-1.14; p-value: 0.02) genotypes.These results provide novel insights on a potential mechanism through which a SMAD7 variant, previously identified as a susceptibility locus for colorectal cancer, and BMI may influence colorectal cancer risk for women. |
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| 700 | 1 | _ | |a Lin, Yi |b 1 |
| 700 | 1 | _ | |a Bien, Stephanie A |b 2 |
| 700 | 1 | _ | |a Figueiredo, Jane C |b 3 |
| 700 | 1 | _ | |a Harrison, Tabitha A |b 4 |
| 700 | 1 | _ | |a Guinter, Mark J |b 5 |
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| 700 | 1 | _ | |a Chan, Andrew T |b 8 |
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| 700 | 1 | _ | |a Gallinger, Steven J |b 10 |
| 700 | 1 | _ | |a Gapstur, Susan M |b 11 |
| 700 | 1 | _ | |a Giles, Graham G |b 12 |
| 700 | 1 | _ | |a Giovannucci, Edward |b 13 |
| 700 | 1 | _ | |a Gruber, Stephen B |b 14 |
| 700 | 1 | _ | |a Gunter, Marc |b 15 |
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| 700 | 1 | _ | |a Jacobs, Eric J |b 17 |
| 700 | 1 | _ | |a Jenkins, Mark A |b 18 |
| 700 | 1 | _ | |a Marchand, Loic Le |b 19 |
| 700 | 1 | _ | |a Li, Li |b 20 |
| 700 | 1 | _ | |a McLaughlin, John R |b 21 |
| 700 | 1 | _ | |a Murphy, Neil |b 22 |
| 700 | 1 | _ | |a Milne, Roger L |b 23 |
| 700 | 1 | _ | |a Newcomb, Polly A |b 24 |
| 700 | 1 | _ | |a Newton, Christina |b 25 |
| 700 | 1 | _ | |a Ogino, Shuji |b 26 |
| 700 | 1 | _ | |a Potter, John D |b 27 |
| 700 | 1 | _ | |a Rennert, Gad |b 28 |
| 700 | 1 | _ | |a Rennert, Hedy S |b 29 |
| 700 | 1 | _ | |a Robinson, Jennifer |b 30 |
| 700 | 1 | _ | |a Sakoda, Lori C |b 31 |
| 700 | 1 | _ | |a Slattery, Martha L |b 32 |
| 700 | 1 | _ | |a Song, Yiqing |b 33 |
| 700 | 1 | _ | |a White, Emily |b 34 |
| 700 | 1 | _ | |a Woods, Michael O |b 35 |
| 700 | 1 | _ | |a Casey, Graham |b 36 |
| 700 | 1 | _ | |a Hsu, Li |b 37 |
| 700 | 1 | _ | |a Peters, Ulrike |b 38 |
| 773 | _ | _ | |a 10.1093/jnci/djaa058 |g p. djaa058 |0 PERI:(DE-600)1465951-7 |n 1 |p 38-47 |t Journal of the National Cancer Institute |v 113 |y 2021 |x 1460-2105 |
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