TY  - JOUR
AU  - Mynarek, Martin
AU  - von Hoff, Katja
AU  - Pietsch, Torsten
AU  - Ottensmeier, Holger
AU  - Warmuth-Metz, Monika
AU  - Bison, Brigitte
AU  - Pfister, Stefan
AU  - Korshunov, Andrey
AU  - Sharma, Tanvi
AU  - Jaeger, Natalie
AU  - Ryzhova, Marina
AU  - Zheludkova, Olga
AU  - Golanov, Andrey
AU  - Rushing, Elisabeth Jane
AU  - Hasselblatt, Martin
AU  - Koch, Arend
AU  - Schüller, Ulrich
AU  - von Deimling, Andreas
AU  - Sahm, Felix
AU  - Sill, Martin
AU  - Riemenschneider, Markus J
AU  - Dohmen, Hildegard
AU  - Monoranu, Camelia Maria
AU  - Sommer, Clemens
AU  - Staszewski, Ori
AU  - Mawrin, Christian
AU  - Schittenhelm, Jens
AU  - Brück, Wolfgang
AU  - Filipski, Katharina
AU  - Hartmann, Christian
AU  - Meinhardt, Matthias
AU  - Pietschmann, Klaus
AU  - Haberler, Christine
AU  - Slavc, Irene
AU  - Gerber, Nicolas U
AU  - Grotzer, Michael
AU  - Benesch, Martin
AU  - Schlegel, Paul Gerhardt
AU  - Deinlein, Frank
AU  - von Bueren, André O
AU  - Friedrich, Carsten
AU  - Juhnke, Björn-Ole
AU  - Obrecht, Denise
AU  - Fleischhack, Gudrun
AU  - Kwiecien, Robert
AU  - Faldum, Andreas
AU  - Kortmann, Rolf Dieter
AU  - Kool, Marcel
AU  - Rutkowski, Stefan
TI  - Nonmetastatic Medulloblastoma of Early Childhood: Results From the Prospective Clinical Trial HIT-2000 and An Extended Validation Cohort.
JO  - Journal of clinical oncology
VL  - 38
IS  - 18
SN  - 1527-7755
CY  - Alexandria, Va.
PB  - American Society of Clinical Oncology
M1  - DKFZ-2020-00879
SP  - 2028-2040
PY  - 2020
N1  - 2020 Jun 20;38(18):2028-2040
AB  - The HIT-2000-BIS4 trial aimed to avoid highly detrimental craniospinal irradiation (CSI) in children < 4 years of age with nonmetastatic medulloblastoma by systemic chemotherapy, intraventricular methotrexate, and risk-adapted local radiotherapy.From 2001-2011, 87 patients received systemic chemotherapy and intraventricular methotrexate. Until 2006, CSI was reserved for nonresponse or progression. After 2006, local radiotherapy was introduced for nonresponders or patients with classic medulloblastoma (CMB) or large-cell/anaplastic medulloblastoma (LCA). DNA methylation profiles of infantile sonic hedgehog-activated medulloblastoma (SHH-INF) were subdivided into iSHH-I and iSHH-II subtypes in the HIT-2000-BIS4 cohort and a validation cohort (n = 71) from the HIT group and Russia.Five years after diagnosis, patients with desmoplastic medulloblastoma (DMB) or medulloblastoma with extensive nodularity (MBEN; n = 42) had 93
LB  - PUB:(DE-HGF)16
C6  - pmid:32330099
DO  - DOI:10.1200/JCO.19.03057
UR  - https://inrepo02.dkfz.de/record/154606
ER  -