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@ARTICLE{Butt:154617,
      author       = {J. A. Butt$^*$ and M. Jenab and M. Pawlita$^*$ and A.
                      Tjonneland and C. Kyrø and M.-C. Boutron-Ruault and F.
                      Carbonnel and C. Dong and R. Kaaks$^*$ and T. Kühn$^*$ and
                      H. Boeing and M. B. Schulze and A. Trichopoulou and A.
                      Karakatsani and C. La Vecchia and D. Palli and C. Agnoli and
                      R. Tumino and C. Sacerdote and S. Panico and B.
                      Bueno-de-Mesquita and R. Vermeulen and I. T. Gram and E.
                      Weiderpass and K. Benjaminsen Borch and J. R. Quirós and A.
                      Agudo and M. Rodríguez-Barranco and C. Santiuste and E.
                      Ardanaz and B. Van Guelpen and S. Harlid and L. Imaz and A.
                      Perez-Cornago and M. J. Gunter and S. Zouiouich and J. Y.
                      Park and E. Riboli and A. J. Cross and A. K. Heath and T.
                      Waterboer$^*$ and D. J. Hughes},
      title        = {{A}ntibody responses to {H}elicobacter pylori and risk of
                      developing colorectal cancer in a {E}uropean cohort.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {29},
      number       = {7},
      issn         = {1538-7755},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2020-00890},
      pages        = {1475-1481},
      year         = {2020},
      note         = {2020 Jul;29(7):1475-1481.#EA:F022#LA:F022#},
      abstract     = {While Helicobacter pylori (H. pylori) is the major cause of
                      gastric cancer, it has also been suggested to be involved in
                      colorectal cancer (CRC) development. However, prospective
                      studies addressing H. pylori and CRC are sparse and
                      inconclusive. We assessed the association of antibody
                      responses to H. pylori proteins with CRC in the European
                      Prospective Investigation into Cancer and Nutrition (EPIC)
                      cohort.We applied H. pylori multiplex serology to measure
                      antibody responses to 13 H. pylori proteins in
                      pre-diagnostic serum samples from 485 CRC cases and 485
                      matched controls nested within the EPIC study. Odds ratios
                      (OR) and $95\%$ confidence intervals (CI) were calculated
                      using multivariable conditional logistic regression to
                      estimate the association of H. pylori overall and
                      protein-specific sero-positivity with odds of developing
                      CRC.Fifty-one percent of CRC cases were H. pylori
                      sero-positive compared to $44\%$ of controls resulting in an
                      OR of 1.36 $(95\%$ CI: 1.00-1.85). Among the 13 individual
                      H. pylori proteins, the association was driven mostly by
                      sero-positivity to Helicobacter cysteine-rich protein C
                      (HcpC) (OR: 1.66, $95\%$ CI: 1.19-2.30) and Vacuolating
                      cytotoxin A (VacA) (OR: 1.34, $95\%$ CI: 0.99-1.82), the
                      latter being non-statistically significant only in the fully
                      adjusted model.In this prospective multi-center European
                      study, antibody responses to H. pylori proteins,
                      specifically HcpC and VacA, were associated with an
                      increased risk of developing CRC.Biological mechanisms for a
                      potential causal role of H. pylori in colorectal
                      carcinogenesis need to be elucidated, and subsequently
                      whether H. pylori eradication may decrease CRC incidence.},
      cin          = {F022 / F020 / C020},
      ddc          = {610},
      cid          = {I:(DE-He78)F022-20160331 / I:(DE-He78)F020-20160331 /
                      I:(DE-He78)C020-20160331},
      pnm          = {316 - Infections and cancer (POF3-316)},
      pid          = {G:(DE-HGF)POF3-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32332031},
      doi          = {10.1158/1055-9965.EPI-19-1545},
      url          = {https://inrepo02.dkfz.de/record/154617},
}