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@ARTICLE{Satta:154620,
author = {G. Satta and M. Loi and N. Becker$^*$ and Y. Benavente and
S. De Sanjose and L. Foretova and A. Staines and M. Maynadie
and A. Nieters and F. Meloni and I. Pilia and M. Campagna
and M. Pau and L. B. Zablotska and P. Cocco},
title = {{O}ccupational exposure to ionizing radiation and risk of
lymphoma subtypes: results of the {E}pilymph {E}uropean
case-control study.},
journal = {Environmental health},
volume = {19},
number = {1},
issn = {1476-069X},
address = {London},
publisher = {BioMed Central},
reportid = {DKFZ-2020-00893},
pages = {43},
year = {2020},
abstract = {Evidence linking risk of lymphoma and B-cell lymphoma
subtypes to ionizing radiation is inconclusive, particularly
at low exposure levels.We investigated risk of lymphoma (all
subtypes), B-cell lymphomas, and its major subtypes,
associated with low-level occupational exposure to ionizing
radiation, in 2346 lymphoma cases and 2463 controls, who
participated in the multicenter EpiLymph case-control study.
We developed a job-exposure matrix to estimate exposure to
ionizing radiation, distinguishing between internal and
external radiation, and we applied it to the lifetime
occupational history of study subjects, We calculated the
Odds Ratio (OR) and its $95\%$ confidence interval $(95\%$
CI) for lymphoma (all subtypes combined), B-cell lymphoma,
and its major subtypes using unconditional, polytomous
logistic regression adjusting for age, gender, and
education.We did not observe an association between exposure
metrics of external and internal radiation and risk of
lymphoma (all subtypes), nor with B-cell lymphoma, or its
major subtypes, at the levels regularly experienced in
occupational settings. An elevated risk of diffuse large B
cell lymphoma was observed among the most likely exposed
study subjects with relatively higher exposure intensity,
which would be worth further investigation.Further
investigation is warranted on risk of B cell lymphoma
subtypes associated with low-level occupational exposure to
external ionizing radiation, and to clarify whether lymphoma
should be included among the cancer outcomes related to
ionizing radiation.},
cin = {C130},
ddc = {610},
cid = {I:(DE-He78)C130-20160331},
pnm = {313 - Cancer risk factors and prevention (POF3-313)},
pid = {G:(DE-HGF)POF3-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:32334593},
doi = {10.1186/s12940-020-00596-9},
url = {https://inrepo02.dkfz.de/record/154620},
}