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@ARTICLE{Gigic:154654,
      author       = {B. Gigic$^*$ and J. Nattenmüller and M. Schneider$^*$ and
                      Y. Kulu and K. L. Syrjala and J. Böhm and P.
                      Schrotz-King$^*$ and H. Brenner$^*$ and G. A. Colditz and J.
                      C. Figueiredo and W. M. Grady and C. I. Li and D. Shibata
                      and E. M. Siegel and A. T. Toriola and H.-U. Kauczor and A.
                      Ulrich and C. M. Ulrich},
      title        = {{T}he {R}ole of {CT}-{Q}uantified {B}ody {C}omposition on
                      {L}ongitudinal {H}ealth-{R}elated {Q}uality of {L}ife in
                      {C}olorectal {C}ancer {P}atients: {T}he {C}olocare {S}tudy.},
      journal      = {Nutrients},
      volume       = {12},
      number       = {5},
      issn         = {2072-6643},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2020-00915},
      pages        = {1247 -},
      year         = {2020},
      note         = {#EA:C120#},
      abstract     = {Obesity, defined by body mass index (BMI), measured at
                      colorectal cancer (CRC) diagnosis has been associated with
                      postoperative complications and survival outcomes. However,
                      BMI does not allow for a differentiation between fat and
                      muscle mass. Computed tomography (CT)-defined body
                      composition more accurately reflects different types of
                      tissue and their associations with health-related quality of
                      life (HRQoL) during the first year of disease, but this has
                      not been investigated yet. We studied the role of visceral
                      and subcutaneous fat area (VFA and SFA) and skeletal muscle
                      mass (SMM) on longitudinally assessed HRQoL in CRC
                      patients.A total of 138 newly diagnosed CRC patients
                      underwent CT scans at diagnosis and completed questionnaires
                      prior to and six and twelve months post-surgery. We
                      investigated the associations of VFA, SFA, and SMM with
                      HRQoL at multiple time points.A higher VFA was associated
                      with increased pain six and twelve months post-surgery (β =
                      0.06, p = 0.04 and β = 0.07, p = 0.01) and with worse
                      social functioning six months post-surgery (β = -0.08, p =
                      0.01). Higher SMM was associated with increased pain twelve
                      months post-surgery (β = 1.03, p < 0.01).CT-quantified body
                      composition is associated with HRQoL scales post-surgery.
                      Intervention strategies targeting a reduction in VFA and
                      maintaining SMM might improve HRQoL in CRC patients during
                      the first year post-surgery.},
      cin          = {C120 / C070 / HD01 / W120},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)W120-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32353960},
      doi          = {10.3390/nu12051247},
      url          = {https://inrepo02.dkfz.de/record/154654},
}