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@ARTICLE{Zwicker:154697,
      author       = {F. Zwicker$^*$ and B. Swartman and P. E. Huber$^*$ and K.
                      Herfarth and J. Debus$^*$ and H. Hauswald},
      title        = {{L}ack of {R}elevant {H}aemogram {C}hanges {D}uring
                      {P}ercutaneous {R}adiotherapy of {L}ocalised {P}rostate
                      {C}ancer.},
      journal      = {In vivo},
      volume       = {34},
      number       = {3},
      issn         = {1791-7549},
      address      = {Kapandriti, Attiki},
      publisher    = {IIAR},
      reportid     = {DKFZ-2020-00955},
      pages        = {1555 - 1563},
      year         = {2020},
      note         = {#EA:E055#},
      abstract     = {In percutaneous radiotherapy dose-distribution and
                      volumetric-load of normal tissue varies in different
                      radiation-techniques. Haematotoxicity may lead to
                      deficiencies of the immune and blood system or to secondary
                      malignancies. Therefore, regular blood-counts are carried
                      out during fractionated radiotherapy. The aim was to
                      investigate patient haemogram courses during radiotherapy of
                      localised prostate-cancer treated with different
                      radiation-techniques (n=3).In this prospective study, blood
                      count changes were examined during fractionated radiotherapy
                      (3D-conformal-RT/step-and-shoot-IMRT/helical-IMRT) on the
                      prostate-region in localised prostate-cancer cases
                      (n=50).The whole patient group displayed a small but
                      significant reduction in leukocytes. This reduction was
                      higher in the two IMRT groups compared to the 3D-group but
                      without any case of leukopenia. Haemoglobin- or
                      thrombocyte-levels did not significantly change.Regardless
                      of the delivery mode used, localised fractionated
                      irradiation of prostate region did not cause any clinically
                      relevant haemogram changes in this study. These findings
                      question the necessity of regular blood counts during
                      fractionated radiotherapy of the prostate region for
                      patients without any risk factors.},
      cin          = {E055 / E050},
      ddc          = {610},
      cid          = {I:(DE-He78)E055-20160331 / I:(DE-He78)E050-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32354962},
      doi          = {10.21873/invivo.11945},
      url          = {https://inrepo02.dkfz.de/record/154697},
}