001     154702
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024 7 _ |a 10.1080/10408398.2020.1757616
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024 7 _ |a 1040-8398
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024 7 _ |a 1549-7852
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024 7 _ |a 2374-9938
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037 _ _ |a DKFZ-2020-00960
041 _ _ |a eng
082 _ _ |a 640
100 1 _ |a Schwingshackl, Lukas
|b 0
245 _ _ |a Impact of intermittent energy restriction on anthropometric outcomes and intermediate disease markers in patients with overweight and obesity: systematic review and meta-analyses.
260 _ _ |a London
|c 2021
|b Taylor and Francis
336 7 _ |a article
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336 7 _ |a Journal Article
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500 _ _ |a 2021;61(8):1293-1304
520 _ _ |a This systematic review aims to investigate the effects of intermittent energy restriction (IER) on anthropometric outcomes and intermediate disease markers. A systematic literature search was conducted in three electronic databases. Randomized controlled trials (RCTs) were included if the intervention lasted ≥12 weeks and IER was compared with either continuous energy restriction (CER) or a usual diet. Random-effects meta-analysis was performed for eight outcomes. Certainty of evidence was assessed using GRADE. Seventeen RCTs with 1328 participants were included. IER in comparison to a usual diet may reduce body weight (mean difference [MD]: -4.83 kg, 95%-CI: -5.46, -4.21; n = 6 RCTs), waist circumference (MD: -1.73 cm, 95%-CI: -3.69, 0.24; n = 2), fat mass (MD: -2.54 kg, 95%-CI: -3.78, -1.31; n = 6), triacylglycerols (MD: -0.20 mmol/L, 95%-CI: -0.38, -0.03; n = 5) and systolic blood pressure (MD: -6.11 mmHg, 95%-CI: -9.59, -2.64; n = 5). No effects were observed for LDL-cholesterol, fasting glucose, and glycosylated-hemoglobin. Both, IER and CER have similar effect on body weight (MD: -0.55 kg, 95%-CI: -1.01, -0.09; n = 13), and fat mass (MD: -0.66 kg, 95%-CI: -1.14, -0.19; n = 10), and all other outcomes. In conclusion, IER improves anthropometric outcomes and intermediate disease markers when compared to a usual diet. The effects of IER on weight loss are similar to weight loss achieved by CER.
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700 1 _ |a Zähringer, Jasmin
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700 1 _ |a Nitschke, Kai
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700 1 _ |a Torbahn, Gabriel
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700 1 _ |a Lohner, Szimonetta
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700 1 _ |a Kühn, Tilman
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700 1 _ |a Fontana, Luigi
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700 1 _ |a Veronese, Nicola
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700 1 _ |a Schmucker, Christine
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700 1 _ |a Meerpohl, Joerg J
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773 _ _ |a 10.1080/10408398.2020.1757616
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