%0 Journal Article
%A Voronina, Natalia
%A Wong, John K L
%A Hübschmann, Daniel
%A Hlevnjak, Mario
%A Uhrig, Sebastian
%A Heilig, Christoph
%A Horak, Peter
%A Kreutzfeldt, Simon
%A Mock, Andreas
%A Stenzinger, Albrecht
%A Hutter, Barbara
%A Fröhlich, Martina
%A Brors, Benedikt
%A Jahn, Arne
%A Klink, Barbara
%A Gieldon, Laura
%A Sieverling, Lina
%A Feuerbach, Lars
%A Chudasama, Priya
%A Beck, Katja
%A Kroiss, Matthias
%A Heining, Christoph
%A Möhrmann, Lino
%A Fischer, Andreas
%A Schröck, Evelin
%A Glimm, Hanno
%A Zapatka, Marc
%A Lichter, Peter
%A Fröhling, Stefan
%A Ernst, Aurélie
%T The landscape of chromothripsis across adult cancer types.
%J Nature Communications
%V 11
%N 1
%@ 2041-1723
%C [London]
%I Nature Publishing Group UK
%M DKFZ-2020-01001
%P 2320
%D 2020
%Z #EA:B420#EA:B060#LA:B420#LA:B060#
%X Chromothripsis is a recently identified mutational phenomenon, by which a presumably single catastrophic event generates extensive genomic rearrangements of one or a few chromosome(s). Considered as an early event in tumour development, this form of genome instability plays a prominent role in tumour onset. Chromothripsis prevalence might have been underestimated when using low-resolution methods, and pan-cancer studies based on sequencing are rare. Here we analyse chromothripsis in 28 tumour types covering all major adult cancers (634 tumours, 316 whole-genome and 318 whole-exome sequences). We show that chromothripsis affects a substantial proportion of human cancers, with a prevalence of 49
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32385320
%R 10.1038/s41467-020-16134-7
%U https://inrepo02.dkfz.de/record/154753