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000154753 1001_ $$0P:(DE-He78)d4a393cd7f001e148c4cb0d380f5b393$$aVoronina, Natalia$$b0$$eFirst author
000154753 245__ $$aThe landscape of chromothripsis across adult cancer types.
000154753 260__ $$a[London]$$bNature Publishing Group UK$$c2020
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000154753 520__ $$aChromothripsis is a recently identified mutational phenomenon, by which a presumably single catastrophic event generates extensive genomic rearrangements of one or a few chromosome(s). Considered as an early event in tumour development, this form of genome instability plays a prominent role in tumour onset. Chromothripsis prevalence might have been underestimated when using low-resolution methods, and pan-cancer studies based on sequencing are rare. Here we analyse chromothripsis in 28 tumour types covering all major adult cancers (634 tumours, 316 whole-genome and 318 whole-exome sequences). We show that chromothripsis affects a substantial proportion of human cancers, with a prevalence of 49% across all cases. Chromothripsis generates entity-specific genomic alterations driving tumour development, including clinically relevant druggable fusions. Chromothripsis is linked with specific telomere patterns and univocal mutational signatures in distinct tumour entities. Longitudinal analysis of chromothriptic patterns in 24 matched tumour pairs reveals insights in the clonal evolution of tumours with chromothripsis.
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000154753 7001_ $$00000-0001-6362-373X$$aWong, John K L$$b1$$eFirst author
000154753 7001_ $$0P:(DE-HGF)0$$aHübschmann, Daniel$$b2
000154753 7001_ $$0P:(DE-He78)aa1da4918a48503d125ee3325c7f135e$$aHlevnjak, Mario$$b3
000154753 7001_ $$0P:(DE-He78)a8e85c1bd89741ab0c2a28032ba81359$$aUhrig, Sebastian$$b4
000154753 7001_ $$0P:(DE-He78)42b6114cd48e033299b2b6ef4bf56cc6$$aHeilig, Christoph$$b5
000154753 7001_ $$0P:(DE-He78)5ea1944c122bc098a81df27a05572719$$aHorak, Peter$$b6
000154753 7001_ $$0P:(DE-He78)e5972dddc3c8d1412db29ba54fed83ba$$aKreutzfeldt, Simon$$b7
000154753 7001_ $$0P:(DE-He78)8f7c3bc1451193551c2458d93222536a$$aMock, Andreas$$b8
000154753 7001_ $$aStenzinger, Albrecht$$b9
000154753 7001_ $$0P:(DE-He78)135e8c8d1dd1b66b8127c3d1e3a9b6a0$$aHutter, Barbara$$b10
000154753 7001_ $$0P:(DE-He78)a15aa7d740f286aad9d8139d515e866c$$aFröhlich, Martina$$b11
000154753 7001_ $$0P:(DE-He78)fc949170377b58098e46141d95c72661$$aBrors, Benedikt$$b12
000154753 7001_ $$0P:(DE-He78)871753841be6a28f30e6fc8c4fa324f7$$aJahn, Arne$$b13
000154753 7001_ $$00000-0002-9034-0329$$aKlink, Barbara$$b14
000154753 7001_ $$0P:(DE-He78)faeda50a6b472b04206eb573f9894d21$$aGieldon, Laura$$b15
000154753 7001_ $$0P:(DE-He78)a82e5b3870b674f83ff39df31c487ac7$$aSieverling, Lina$$b16
000154753 7001_ $$0P:(DE-He78)75e2afb3ea0812786cc551c10679b67d$$aFeuerbach, Lars$$b17
000154753 7001_ $$0P:(DE-He78)97208bef945f0ab6bf33ed9925685de4$$aChudasama, Priya$$b18
000154753 7001_ $$0P:(DE-He78)f6b238ac374345c55706521c4f435779$$aBeck, Katja$$b19
000154753 7001_ $$00000-0002-7628-3161$$aKroiss, Matthias$$b20
000154753 7001_ $$0P:(DE-He78)1464357f7ec5faf677a390a414e50c88$$aHeining, Christoph$$b21
000154753 7001_ $$0P:(DE-He78)79e92bc6260b7a24abe4daf4378bf19c$$aMöhrmann, Lino$$b22
000154753 7001_ $$0P:(DE-He78)039283a5d51058ec79156d0ef67132da$$aFischer, Andreas$$b23
000154753 7001_ $$0P:(DE-HGF)0$$aSchröck, Evelin$$b24
000154753 7001_ $$0P:(DE-He78)157277fe62f07df1732f9d126a51d1b9$$aGlimm, Hanno$$b25
000154753 7001_ $$0P:(DE-He78)1beba8f953e7ae7e96e8d3e9a48f10f7$$aZapatka, Marc$$b26
000154753 7001_ $$0P:(DE-He78)e13b4363c5fe858044ef8a39c02c870c$$aLichter, Peter$$b27
000154753 7001_ $$0P:(DE-He78)f0144d171d26dbedb67c9db1df35629d$$aFröhling, Stefan$$b28
000154753 7001_ $$0P:(DE-He78)509fb81813c1911954da583129e8ea57$$aErnst, Aurélie$$b29$$eLast author
000154753 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-020-16134-7$$gVol. 11, no. 1, p. 2320$$n1$$p2320$$tNature Communications$$v11$$x2041-1723$$y2020
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