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@ARTICLE{Voronina:154753,
      author       = {N. Voronina$^*$ and J. K. L. Wong$^*$ and D.
                      Hübschmann$^*$ and M. Hlevnjak$^*$ and S. Uhrig$^*$ and C.
                      Heilig$^*$ and P. Horak$^*$ and S. Kreutzfeldt$^*$ and A.
                      Mock$^*$ and A. Stenzinger and B. Hutter$^*$ and M.
                      Fröhlich$^*$ and B. Brors$^*$ and A. Jahn$^*$ and B.
                      Klink$^*$ and L. Gieldon and L. Sieverling$^*$ and L.
                      Feuerbach$^*$ and P. Chudasama$^*$ and K. Beck$^*$ and M.
                      Kroiss and C. Heining$^*$ and L. Möhrmann$^*$ and A.
                      Fischer$^*$ and E. Schröck$^*$ and H. Glimm$^*$ and M.
                      Zapatka$^*$ and P. Lichter$^*$ and S. Fröhling$^*$ and A.
                      Ernst$^*$},
      title        = {{T}he landscape of chromothripsis across adult cancer
                      types.},
      journal      = {Nature Communications},
      volume       = {11},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2020-01001},
      pages        = {2320},
      year         = {2020},
      note         = {#EA:B420#EA:B060#LA:B420#LA:B060#},
      abstract     = {Chromothripsis is a recently identified mutational
                      phenomenon, by which a presumably single catastrophic event
                      generates extensive genomic rearrangements of one or a few
                      chromosome(s). Considered as an early event in tumour
                      development, this form of genome instability plays a
                      prominent role in tumour onset. Chromothripsis prevalence
                      might have been underestimated when using low-resolution
                      methods, and pan-cancer studies based on sequencing are
                      rare. Here we analyse chromothripsis in 28 tumour types
                      covering all major adult cancers (634 tumours, 316
                      whole-genome and 318 whole-exome sequences). We show that
                      chromothripsis affects a substantial proportion of human
                      cancers, with a prevalence of $49\%$ across all cases.
                      Chromothripsis generates entity-specific genomic alterations
                      driving tumour development, including clinically relevant
                      druggable fusions. Chromothripsis is linked with specific
                      telomere patterns and univocal mutational signatures in
                      distinct tumour entities. Longitudinal analysis of
                      chromothriptic patterns in 24 matched tumour pairs reveals
                      insights in the clonal evolution of tumours with
                      chromothripsis.},
      cin          = {B420 / B060 / HD01 / B330 / B340 / DD01 / B390},
      ddc          = {500},
      cid          = {I:(DE-He78)B420-20160331 / I:(DE-He78)B060-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)B330-20160331 /
                      I:(DE-He78)B340-20160331 / I:(DE-He78)DD01-20160331 /
                      I:(DE-He78)B390-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32385320},
      doi          = {10.1038/s41467-020-16134-7},
      url          = {https://inrepo02.dkfz.de/record/154753},
}