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| 001 | 154800 | ||
| 005 | 20240229133504.0 | ||
| 024 | 7 | _ | |a 10.1007/s00259-020-04777-z |2 doi |
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| 024 | 7 | _ | |a 1432-105X |2 ISSN |
| 024 | 7 | _ | |a 1619-7070 |2 ISSN |
| 024 | 7 | _ | |a 1619-7089 |2 ISSN |
| 037 | _ | _ | |a DKFZ-2020-01038 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Koerber, Stefan A |b 0 |
| 245 | _ | _ | |a Clinical outcome of PSMA-guided radiotherapy for patients with oligorecurrent prostate cancer. |
| 260 | _ | _ | |a Heidelberg [u.a.] |c 2021 |b Springer-Verl. |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1614947446_29979 |2 PUB:(DE-HGF) |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2021 Jan;48(1):143-151 |
| 520 | _ | _ | |a First-line treatment of patients with recurrent, metastatic prostate cancer involves hormone therapy with or without additional systemic therapies. Prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) allows the detection of oligometastatic disease that may be amenable to image-guided radiotherapy. The current study classifies the type and localization of metastases and the clinical outcome of PSMA-PET/CT-guided radiotherapy to selected metastases.Between 2011 and 2019, 86 patients with recurrent, oligometastatic prostate carcinoma were identified by PSMA-PET/CT and were treated with image-guided radiotherapy of their metastases. Sites of relapse were characterized, and the primary endpoint overall survival (OS), biochemical progression-free survival (bPFS), and androgen deprivation therapy (ADT)-free survival were tabulated.In total, 37% of the metastases were bone metastases, 48% were pelvic nodal metastases, and 15% were nodal metastases outside of the pelvis. After PSMA-guided radiotherapy, a biochemical response was detected in 83% of the cohort. A statistically significant decrease in the standard uptake value (SUV) was seen in irradiated metastases. After a median follow-up of 26 months, the 3-year OS and bPFS were 84% and 55%, respectively. The median time of ADT-free survival was 13.5 months. A better clinical outcome was observed for patients receiving concomitant ADT or more than 24 fractions of radiation.PSMA-guided radiotherapy is a promising therapeutic approach with excellent infield control for men with oligorecurrent prostate carcinoma. However, prospective, randomized trials are necessary to determine if this approach confers a survival advantage. |
| 536 | _ | _ | |a 315 - Bildgebung und Radioonkologie (POF4-315) |0 G:(DE-HGF)POF4-315 |c POF4-315 |x 0 |f POF IV |
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| 700 | 1 | _ | |a Sprute, Katharina |b 1 |
| 700 | 1 | _ | |a Kratochwil, Clemens |b 2 |
| 700 | 1 | _ | |a Winter, Erik |b 3 |
| 700 | 1 | _ | |a Haefner, Matthias F |b 4 |
| 700 | 1 | _ | |a Katayama, Sonja |b 5 |
| 700 | 1 | _ | |a Schlampp, Ingmar |b 6 |
| 700 | 1 | _ | |a Herfarth, Klaus |b 7 |
| 700 | 1 | _ | |a Kopka, Klaus |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Afshar-Oromieh, Ali |b 9 |
| 700 | 1 | _ | |a Zschaebitz, Stefanie |b 10 |
| 700 | 1 | _ | |a Holland-Letz, Tim |0 P:(DE-He78)457c042884c901eb0a02c18bb1d30103 |b 11 |
| 700 | 1 | _ | |a Choyke, Peter L |b 12 |
| 700 | 1 | _ | |a Jaeger, Dirk |b 13 |
| 700 | 1 | _ | |a Hohenfellner, Markus |b 14 |
| 700 | 1 | _ | |a Haberkorn, Uwe |0 P:(DE-He78)13a0afba029f5f64dc18b25ef7499558 |b 15 |u dkfz |
| 700 | 1 | _ | |a Debus, Juergen |0 P:(DE-HGF)0 |b 16 |
| 700 | 1 | _ | |a Giesel, Frederik |0 P:(DE-He78)5ca7e97b2769bb97f8c73431c6566b94 |b 17 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1007/s00259-020-04777-z |0 PERI:(DE-600)2098375-X |n 1 |p 143-151 |t European journal of nuclear medicine and molecular imaging |v 48 |y 2021 |x 1619-7089 |
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